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Cat. No. Product Name Target Signaling Pathways
T63914 Estrogen receptor antagonist 3

Estrogen receptor antagonist 3 是雌激素受体 (ER) 的有效降解剂。雌激素信号系统在调节细胞生长、分化和凋亡 (apoptosis) 中发挥着重要作用。Estrogen receptor antagonist 4 对癌症疾病表现出研究潜力。
T60115 EM-651

2H-1-Benzopyran-7-ol, 3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-, (2R)-

EM-651 (2H-1-Benzopyran-7-ol, 3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-, (2R)-)是EM-652的一种活性较低的对映体,IC50=20.0 nM。EM-652是一种口服有效的、选择性的雌激素受体拮抗剂,IC50=0.44nM。

化合物

Estrogen receptor antagonist 3
Cat.No: T63914
Synonym:
Target:
EM-651
Cat.No: T60115
Synonym: 2H-1-Benzopyran-7-ol, 3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-, (2R)-
Target:
Cat. No. Product Name Target Signaling Pathways
TN5456 Isoerysenegalensein E

Isoerysenegalensein E shows anti-estrogenic activity comparable to that of 4-hydroxytamoxifen, a typical estrogen receptor antagonist. It shows significant cytotoxicity against HL-60 cells, it induces apoptosis in HL-60 cells through activation of the cas
T35667 Napyradiomycin A1

Napyradiomycin A1

Napyradiomycin A1is a fungal metabolite originally isolated fromC. rubraand has diverse biological activities.1,2It is active againstS. aureus,M. luteus,B. anthracis,C. bovis, andM. smegmatis(MICs = 1.56-12.5 μg/ml).1Napyradiomycin A1is an estrogen receptor antagonist (IC50= 4.2 μM in rat uterine homogenates).2It also inhibits mitochondrial NADH:ubiquinone oxidoreductase (complex I) and succinate:ubiquinone oxidoreductase (complex II) activities in bovine heart homogenates (IC50s = 20 and 9.7 μM...

天然产物

Isoerysenegalensein E
Cat.No: TN5456
Synonym:
Target:
Napyradiomycin A1
Cat.No: T35667
Synonym: Napyradiomycin A1
Target:
TargetMol Loading
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