Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8834 |
EST64454 hydrochloride
EST64454 |
Sigma receptor | GPCR/G Protein |
EST64454 hydrochloride (EST64454) 是一种可口服的选择性sigma-1受体拮抗剂,Ki 为 22 nM。它有用于疼痛的研究潜力。 | |||
T9306 |
EST64454 Maleic acid salt
|
Others | Others |
EST64454 Maleic acid salt 是EST64454的马来酸盐形式。EST64454是一种用于治疗疼痛的高可溶性σ1受体拮抗剂临床候选药物。 | |||
T70908 |
EST64454 free base
|
||
EST64454 is a σ1 receptor (σ1R) antagonist clinical candidate for the treatment of pain. EST64454 shows an outstanding aqueous solubility, which together with its high permeability in Caco-2 cells will allow its classification as a BCS class I compound. It also shows high metabolic stability. |