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Search Results for " eif2ak2 "

Targets Recommended: PROTACs

1

抑制剂 & 化合物

13

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T74644	DB0614	PROTACs	PROTAC
	DB1113 (Example 24) 是一种靶向蛋白激酶降解的双功能化合物。DB1113 可降解ABL1，ABL2，BLK，CDK11B，CDK4，CSK，EPHA3，FER，GAK，LIMK1，MAP3K20，MAP4K1，MAP4K2，MAP4K3，MAP4K5，MAPK14，MAPK7，MAPK8，MAPK9，MAPKAPK2，MAPKAPK3，NLK，PDIK1L，PTK2B，RIPK1，RPS6KA1，RPS6KA3，SIK2，SIK3，STK35，TNK2 和ULK1。DB1113 可用于研究异常激酶活性介导的疾病或紊乱。

化合物

Cat.No: T74644

Target: PROTACs

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01556	EIF2AK2 Protein, Human, Recombinant (His) EIF2AK2	Human	P. pastoris (Yeast)
	EIF2AK2 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 64.0 kDa and the accession number is P19525.
TMPH-03670	Vaccinia virus (strain Copenhagen) K3 Protein (His & SUMO)	VACV	E. coli
	Viral mimic of eIF-2-alpha that acts as a pseudosubstrate for EIF2AK2/PKR kinase. Inhibits therefore eIF-2-alpha phosphorylation by host EIF2AK2/PKR kinase and prevents protein synthesis shutoff. Vaccinia virus (strain Copenhagen) K3 Protein (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 26.5 kDa and the accession number is P20639.
TMPH-03671	Vaccinia virus (strain Western Reserve) K3 Protein (His)	VACV	P. pastoris (Yeast)
	Viral mimic of eIF-2-alpha that acts as a pseudosubstrate for EIF2AK2/PKR kinase. Inhibits therefore eIF-2-alpha phosphorylation by host EIF2AK2/PKR kinase and prevents protein synthesis shutoff. Vaccinia virus (strain Western Reserve) K3 Protein (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 12.6 kDa and the accession number is P18378.
TMPH-02358	Influenza B (strain B/Lee/1940) Non-structural protein 1 (His)	Influenza B	E. coli
	Binds and inhibits the conjugation of the ubiquitin-like G1P2/ISG15 protein to its target proteins. Since G1P2/ISG15 is an early antiviral protein, NS1 may inhibit the host antiviral response. Prevents EIF2AK2/PKR activation, either by binding double strand RNA or by interacting directly with EIF2AK2/PKR. Also binds poly(A) and U6 snRNA.
TMPH-03672	Vaccinia virus (strain Western Reserve) K3 Protein (His & SUMO)	VACV	E. coli
	Viral mimic of eIF-2-alpha that acts as a pseudosubstrate for EIF2AK2/PKR kinase. Inhibits therefore eIF-2-alpha phosphorylation by host EIF2AK2/PKR kinase and prevents protein synthesis shutoff. Vaccinia virus (strain Western Reserve) K3 Protein (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 26.6 kDa and the accession number is P18378.
TMPH-03404	Reovirus type 3 (strain Dearing) Outer capsid protein sigma-3 (His)	Reo-3	E. coli
	Stimulates translation by blocking the activation of the dsRNA-dependent protein kinase EIF2AK2/PKR, thereby inhibiting the host interferon response. Sigma3 prevents the activation of EIF2AK2 by competing with the kinase for dsRNA-binding.; The viral outer shell polypeptides, of which sigma-3 is one, impose structural constraints that prevent elongation of nascent transcripts by the RNA-dependent RNA polymerase lambda-3. Reovirus type 3 (strain Dearing) Outer capsid protein sigma-3 (His) is expr...
TMPH-02209	TRAF5 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.
TMPH-03415	Rift valley fever virus (RVFV) (strain ZH-548 M12) Non-structural protein S (His & Myc)	RVFV	E. coli
	Plays a role in the escape of host innate immune response by promoting the degradation of host EIF2AK2/PKR and inhibiting host transcription. Cytoplasmic NSs interacts with host FBXW11 to degrade PKR whereas nuclear pool binds to host FBXO3 to target TFIIH subunit GTF2H1 for proteasomal degradation. Forms filaments in the nucleus that may sequester NSs binding partners, causing cell cycle arrest. Rift valley fever virus (RVFV) (strain ZH-548 M12) Non-structural protein S (His & Myc) is expressed...
TMPH-02349	Influenza A H1N1 (strain A/Malaysia:Malaya/302/1954) Non-structural protein 1 (His & Myc)	H1N1	E. coli
	Prevents the establishment of the cellular antiviral state by inhibiting TRIM25-mediated DDX58 ubiquitination, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors IRF3 and IRF7. Prevents human EIF2AK2/PKR activation, either by binding double-strand RNA, or by interacting directly with EIF2AK2/PKR. This function may be important at the very beginning of the infection, when NS1 is mainly present in the cytoplasm. Also ...
TMPH-03733	Zaire ebolavirus (strain Kikwit-95) VP35 Protein (His & Myc)	ZEBOV	HEK293 Cells
	Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Acts as a polymerase cofactor in the RNA polymerase transcription and replication complexes. Serves as nucleoprotein/NP monomer chaperone prior to the formation of the large oligomeric RNA-bound complexes. Regulates RNA synthesis by modulating NP-RNA interactions and interacting with DYNLL1. VP35-NP interaction controls the switch between RNA-bound NP and free NP and thus the switch between gen...
TMPH-03732	Zaire ebolavirus (strain Kikwit-95) VP35 Protein (E. col, His & Myc)	ZEBOV	E. coli
	Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Acts as a polymerase cofactor in the RNA polymerase transcription and replication complexes. Serves as nucleoprotein/NP monomer chaperone prior to the formation of the large oligomeric RNA-bound complexes. Regulates RNA synthesis by modulating NP-RNA interactions and interacting with DYNLL1. VP35-NP interaction controls the switch between RNA-bound NP and free NP and thus the switch between gen...
TMPH-01248	ADAR Protein, Human, Recombinant (His & SUMO) ADAR1,IFI-4,136 kDa double-stranded RNA-binding protein,Inte...	Human	E. coli
	Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences duri...
TMPH-01552	IRF1 Protein, Human, Recombinant (GST & His)	Human	Baculovirus Insect Cells
	Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired imm...

重组蛋白

EIF2AK2 Protein, Human, Recombinant (His)

Cat.No: TMPH-01556

Species: Human

Expression System: P. pastoris (Yeast)

Vaccinia virus (strain Copenhagen) K3 Protein (His & SUMO)

Cat.No: TMPH-03670

Species: VACV

Expression System: E. coli

Vaccinia virus (strain Western Reserve) K3 Protein (His)

Cat.No: TMPH-03671

Species: VACV

Expression System: P. pastoris (Yeast)

Influenza B (strain B/Lee/1940) Non-structural protein 1 (His)

Cat.No: TMPH-02358

Species: Influenza B

Expression System: E. coli

Vaccinia virus (strain Western Reserve) K3 Protein (His & SUMO)

Cat.No: TMPH-03672

Species: VACV

Expression System: E. coli

Reovirus type 3 (strain Dearing) Outer capsid protein sigma-3 (His)

Cat.No: TMPH-03404

Species: Reo-3

Expression System: E. coli

TRAF5 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02209

Species: Human

Expression System: E. coli

Rift valley fever virus (RVFV) (strain ZH-548 M12) Non-structural protein S (His & Myc)

Cat.No: TMPH-03415

Species: RVFV

Expression System: E. coli

Influenza A H1N1 (strain A/Malaysia:Malaya/302/1954) Non-structural protein 1 (His & Myc)

Cat.No: TMPH-02349

Species: H1N1

Expression System: E. coli

Zaire ebolavirus (strain Kikwit-95) VP35 Protein (His & Myc)

Cat.No: TMPH-03733

Species: ZEBOV

Expression System: HEK293 Cells

Zaire ebolavirus (strain Kikwit-95) VP35 Protein (E. col, His & Myc)

Cat.No: TMPH-03732

Species: ZEBOV

Expression System: E. coli

ADAR Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01248

Species: Human

Expression System: E. coli

IRF1 Protein, Human, Recombinant (GST & His)

Cat.No: TMPH-01552

Species: Human

Expression System: Baculovirus Insect Cells

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