Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3458 |
EED226
|
Histone Methyltransferase | Chromatin/Epigenetic |
EED226 是多梳抑制复合物 2 抑制剂,是一种有效的、选择性的、可口服的胚胎外胚层发育 (EED) 抑制剂,IC50 为 22 nM,具有强抗肿瘤活性。当 H3K27me0 肽用作体外酶法测定的底物时,它抑制 PRC2的 IC50为 23.4 nM。 | |||
T17931 |
EED226-COOH
|
Others | Others |
EED226-COOH, derived from EED226, serves as a ligand targeting the EED protein for PROTAC applications. It attaches to a VHL ligand through a linker, culminating in the formation of UNC6852, which specifically degrades PRC2[1]. |