Cat. No. | Product Name | Target | Signaling Pathways |
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T62147 |
DprE1-IN-4
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DprE1-IN-4 是一种有效的、非共价的 DprE1 抑制剂 (IC50: 0.90 μg/mL)。DprE1-IN-4 体外活性较强,能够抑制结核 H37Rv (MIC50: 0.12 μg/ml) 和耐药结核菌株 (MIC50: 0.24 μg/ml)。DprE1-IN-4 具有可接受的药代动力学特性,并且在急性肺结核小鼠模型中具有明显的杀菌作用。 | |||
T79442 |
DprE1-IN-7
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DprE1-IN-7 (Compound 64) 是一款具有抗结核活性的DprE1抑制剂,对Mtb H37Rv菌株表现出明显的功效(MIC: 4 μM),并对耐药分枝杆菌株也显示出活性。此化合物在微粒体中稳定性强,并具有中等的清除速率。 | |||
T79440 |
DprE1-IN-5
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DprE1-IN-5(Compound 10)为一种DprE1抑制剂,对Mtb H37Rv菌株表现出抗结核活性(MIC: 4 μM),并对耐药菌株具有抗分枝杆菌效果,同时展现出较高的微粒体稳定性。 | |||
T79441 |
DprE1-IN-6
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DprE1-IN-6(Compound 56)是DprE1的一种抑制剂,对Mtb H37Rv菌株表现出抗结核活性(MIC: 4 μM),同时也对耐药分枝杆菌株有抗菌效果。该化合物具有较强的微粒体稳定性以及中等的清除速率。 | |||
T37880 |
OPC-167832
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OPC-167832 is a potent and orally active dprE1 Inhibitor with an IC50 of 0.258 μM. OPC-167832 has antituberculosis activity and can be used for the research of tuberculosis caused by Mycobacterium tuberculosis[1]. OPC-167832 exhibits very low MICs against laboratory strains of M. tuberculosis H37Rv (MIC: 0.0005 μg/ml) and Kurono (MIC: 0.0005 μg/ml) and strains with monoresistance to rifampin (RIF), isoniazid (INH), ethambutol (EMB), streptomycin (STR), and pyrazinamide (PZA) (MIC: 0.00024-0.001 ... |