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Cat. No.	Product Name	Target	Signaling Pathways
T37722	Diprovocim-1
	Diprovocim-1 is an agonist of the toll-like receptor 1/2 heterodimer.1It induces TNF-α release in THP-1 cells (EC50= 110 pM), an effect that can be inhibited by anti-TLR1 or anti-TLR2 antibodies. Diprovocim-1 (10 mg/kg) increases the production of ovalbumin-specific IgG1 in wild-type, but notTLR2-/-, mice sensitized to ovalbumin.2It also enhances anti-PD-L1 antibody-induced activation of cytotoxic T lymphocytes, reduction of tumor growth, and increases in survival in a B16/F10 murine melanoma mo...
T74890	Diprovocim-X
	Diprovocim-X (compound 35) 为有效的TLR1/TLR2激动剂，其对hTLR1/TLR2和mTLR1/TLR2的EC50值分别为0.14 nM和0.75 nM。此化合物在小鼠体内作为佐剂使用时，能有效激发适应性免疫反应。