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Search Results for " dna-directed dna polymerase "

Targets Recommended: DNA/RNA Synthesis

11

抑制剂 & 化合物

8

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T7655	Fialuridine DRG-0098,FIAU,非阿尿苷	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Fialuridine (DRG-0098) 是一种 DNA 导向的 DNA 聚合酶抑制剂，可能用于治疗 HBV 感染，在体外和体内对乙型肝炎病毒具有有效的活性。
T28234	Omaciclovir ABT091,H2G,ABT 091,(-)-2HM-HBG,ABT-091,H 2G	Others	Others
	Omaciclovir is a DNA-directed DNA polymerase inhibitor.
T27204	DPC-963 DMP 963,DMP963,DMP-963,DPC 963,DPC963	Others	Others
	DPC-963 is a RNA-directed DNA polymerase inhibitor.
T26400	7U-85 Hydrochloride BW A 7U,7U-85,7U 85,7U85,BW-A-7U	Others	Others
	7U-85 Hydrochloride, a DNA-directed DNA polymerase inhibitor, is used potentially for the treatment of cancer.
T19688	Lodenosine FddA,3'-dideoxyarabinosyladenine,Fddl,2'-F-dd-ara-A,2'-Fluoro-2',DDG-1	Others	Others
	Lodenosine is an inhibitor of RNA-directed DNA polymerase, and potentially for the treatment of HIV.
T28492	R-18893 R18893	Others	Others
	R-18893, a RNA-directed DNA polymerase inhibitor, is used potentially for the treatment of HIV-1 infection.
T26963	CBR-2092 TNP2092,CBR2092,TNP-2092,TNP 2092	Others	Others
	CBR-2092 is a DNA-directed RNA polymerase and DNA topoisomerase inhibitor. CBR-2092 exhibited rifampin-like potency as an inhibitor of RNA polymerase, was an equipotent (balanced) inhibitor of DNA gyrase and DNA topoisomerase IV, and retained activity against a prevalent quinolone-resistant variant. Studies of mutant strains that exhibited reduced susceptibility to CBR-2092 further substantiated RNA polymerase as the primary cellular target of CBR-2092, with DNA gyrase and DNA topoisomerase IV b...
T28585	Ro 31-8588 Ro-31-8588	Others	Others
	Talviraline is a RNA-directed DNA polymerase inhibitor. HBY 097 is a highly potent inhibitor of HIV-1 replication and HIV-1 induced cell killing in a variety of human cell lines as well as in fresh human peripheral blood lymphocytes and macrophages.
T19689	Raluridine FddClUrd,935U-83,FCU,DRG-0215,BW-935U-83	Others	Others
	Raluridine is a RNA-directed DNA polymerase inhibitor potentially for the treatment of HIV infection. 935U83 inhibited virus growth with an average 50% inhibitory concentration (IC50: 1.8 microM) corresponding IC50s were 0.10 microM for FLT (3'-deoxy-3'-f
T28494	R-82913 NSC 637653, 9-Cl-Tibo,R 82913,R82913. 9-Cmbib	Others	Others
	R-82913 is a RNA-directed DNA polymerase inhibitor. R 82913 reduce 5-HT2 receptor-mediated DOI-head-shakes in mice. R82913 inhibited the replication of thirteen different strains of HIV-1 in CEM cells with a median IC50 of 0.15 microM. R82913 was 20-fold
T69931	MFH290	Others	Others
	MFH290 is a novel cysteine (Cys)-directed covalent inhibitor of CDK12/13. MFH290 forms a covalent bond with Cys-1039 of CDK12, exhibits excellent kinome selectivity, inhibits the phosphorylation of serine-2 in the C-terminal domain (CTD) of RNA-polymerase II (Pol II), and reduces the expression of key DNA damage repair genes. Importantly, these effects were demonstrated to be CDK12-dependent as mutation of Cys-1039 rendered the kinase refractory to MFH290 and restored Pol II CTD phosphorylation ...

化合物

Cat.No: T7655

Synonym: DRG-0098,FIAU,非阿尿苷

Target: DNA/RNA Synthesis

Cat.No: T28234

Synonym: ABT091,H2G,ABT 091,(-)-2HM-HBG,ABT-091,H 2G

Target: Others

Cat.No: T27204

Synonym: DMP 963,DMP963,DMP-963,DPC 963,DPC963

Target: Others

7U-85 Hydrochloride

Cat.No: T26400

Synonym: BW A 7U,7U-85,7U 85,7U85,BW-A-7U

Target: Others

Cat.No: T19688

Synonym: FddA,3'-dideoxyarabinosyladenine,Fddl,2'-F-dd-ara-A,2'-Fluoro-2',DDG-1

Target: Others

Cat.No: T28492

Synonym: R18893

Target: Others

Cat.No: T26963

Synonym: TNP2092,CBR2092,TNP-2092,TNP 2092

Target: Others

Cat.No: T28585

Synonym: Ro-31-8588

Target: Others

Cat.No: T19689

Synonym: FddClUrd,935U-83,FCU,DRG-0215,BW-935U-83

Target: Others

Cat.No: T28494

Synonym: NSC 637653, 9-Cl-Tibo,R 82913,R82913. 9-Cmbib

Target: Others

Cat.No: T69931

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00523	DNA-directed DNA polymerase Protein, Enterobacteria phage RB69, Recombinant (His & Myc) Gp43,DNA-directed DNA	Escherichia phage RB69	E. coli
	Replicates the viral genomic DNA. This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction for proofreading purpose. DNA-directed DNA polymerase Protein, Enterobacteria phage RB69, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 35.4 kDa and the accession number is Q38087.
TMPH-00533	T7 RNA polymerase Protein, Enterobacteria phage T7, Recombinant (His & Myc) T7 RNA polymerase,DNA-directe...	Escherichia phage T7	E. coli
	Highly processive DNA-dependent RNA polymerase that catalyzes the transcription of class II and class III viral genes. Recognizes a specific promoter sequence and enters first into an 'abortive phase' where very short transcripts are synthesized and released before proceeding to the processive transcription of long RNA chains. Unwinds the double-stranded DNA to expose the coding strand for templating. Participates in the initiation of viral DNA replication presumably by making primers accessible...
TMPH-01244	POLM Protein, Human, Recombinant (His) DNA-directed DNA	Human	E. coli
	Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination. POLM Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 58.8 kDa and the accession number is Q9NP87.
TMPH-01246	POLR3A Protein, Human, Recombinant (His) RNA polymerase III subunit C160,RNA polymerase<...	Human	E. coli
	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft ...
TMPH-00505	RPB1 Protein, Drosophila melanogaster, Recombinant (His) RNA polymerase II subunit A,DNA-<...	Fruit fly	P. pastoris (Yeast)
	RPB1 Protein, Drosophila melanogaster, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 33.6 kDa and the accession number is P04052.
TMPH-01245	POLM Protein, Human, Recombinant (His & Myc) DNA-directed DNA	Human	Baculovirus Insect Cells
	Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination. POLM Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 58.8 kDa and the accession number is Q9NP87.
TMPH-01247	POLR3K Protein, Human, Recombinant (His) RNA polymerase III subunit C11,POLR3K,RNA polym...	Human	Baculovirus Insect Cells
	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase I...
TMPH-00811	Hepatitis delta virus genotype I (HDV) Small delta antigen Protein (His & Myc) Small delta antigen,p24	HDV	P. pastoris (Yeast)
	Promotes both transcription and replication of genomic RNA. Following virus entry into host cell, provides nuclear import of HDV RNPs thanks to its nuclear localization signal. May interact with host RNA polymerase II thereby changing its template requirement from DNA to RNA. RNA pol II complex would then acts as an RNA-directed RNA polymerase, and transcribe and replicate HDV genome. Hepatitis delta virus genotype I (HDV) Small delta antigen Protein (His & Myc) is expressed in yeast with N-6xHi...

重组蛋白

DNA-directed DNA polymerase Protein, Enterobacteria phage RB69, Recombinant (His & Myc)

Cat.No: TMPH-00523

Species: Escherichia phage RB69

Expression System: E. coli

T7 RNA polymerase Protein, Enterobacteria phage T7, Recombinant (His & Myc)

Cat.No: TMPH-00533

Species: Escherichia phage T7

Expression System: E. coli

POLM Protein, Human, Recombinant (His)

Cat.No: TMPH-01244

Species: Human

Expression System: E. coli

POLR3A Protein, Human, Recombinant (His)

Cat.No: TMPH-01246

Species: Human

Expression System: E. coli

RPB1 Protein, Drosophila melanogaster, Recombinant (His)

Cat.No: TMPH-00505

Species: Fruit fly

Expression System: P. pastoris (Yeast)

POLM Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01245

Species: Human

Expression System: Baculovirus Insect Cells

POLR3K Protein, Human, Recombinant (His)

Cat.No: TMPH-01247

Species: Human

Expression System: Baculovirus Insect Cells

Hepatitis delta virus genotype I (HDV) Small delta antigen Protein (His & Myc)

Cat.No: TMPH-00811

Species: HDV

Expression System: P. pastoris (Yeast)

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