Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T15141 |
DM4
Ravtansine,美登素 DM4 |
Others; Microtubule Associated | Cytoskeletal Signaling; Others |
DM4 (Ravtansine)可用于制备抗体药物偶联物,是抗微管蛋白剂。 它抑制细胞分裂。 | |||
T11059 |
DM4-SMe
|
Others | Others |
DM4-SMe is a cytotoxic part of antibody-drug conjugates (ADCs) and a metabolite of antibody-maytansin conjugates (AMCs) and tubulin inhibitors, which can also be stabilized by disulfide bonds or thioether The bond binds to the antibody. The IC50 of DM4-SM | |||
T13766 |
Maytansinoid DM4
|
Others | Others |
Maytansinoid DM4, a thiol-containing maytansine derivative, is a highly potent cytotoxic moiety utilized in ADC applications. | |||
T17834 |
DM4-SPDP
|
Others | Others |
DM4-SPDP, a drug-linker conjugate, integrates the antitubulin agent DM4 with the linker SMCC, facilitating the creation of antibody drug conjugates[1]. Additionally, SPDP serves as a short-chain crosslinker enabling amine-to-sulfhydryl conjugation, leveraging NHS-ester and pyridyldithiol groups to establish cleavable (reducible) disulfide bonds with cysteine sulfhydryls[2][3]. | |||
T18701 |
SPDB-DM4
|
Others | Others |
SPDB-DM4 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications, employing the maytansine-based payload DM4 (a tubulin inhibitor) connected through a SPDB linker. This compound demonstrates significant anti-tumor efficacy. | |||
T17833 |
DM4-SMCC
|
Others | Others |
DM4-SMCC, a non-cleavable drug-linker conjugate for antibody-drug conjugates (ADC), leverages the antitumor efficacy of DM4 (an antitubulin agent) through attachment with the SMCC linker, exhibiting antitumor activity[1]. | |||
T18702 |
DBA-DM4
|
Others | Others |
DBA-DM4 is a drug-linker conjugate for antibody-drug conjugate (ADC) synthesis, combining the tubulin inhibitor DM1 with the SPDP linker[1]. | |||
T18730 |
sulfo-SPDB-DM4
|
Others | Others |
Sulfo-SPDB-DM4 is a drug-linker conjugate designed for antibody-drug conjugates (ADCs) that employs the maytansine-based payload (DM4, an antitubulin agent) connected through the sulfo-SPDB linker. | |||
T18731 |
Sulfo-PDBA-DM4
|
Others | Others |
Sulfo-PDBA-DM4 is a drug-linker conjugate for antibody-drug conjugate (ADC) applications, combining the potent tubulin inhibitor DM4 with the gluthatione-cleavable linker Sulfo-PDBA. This configuration harnesses DM4's cytotoxic potential through Sulfo-PDBA's targeted delivery mechanism. | |||
T38682 |
Lys-Nε-SPDB-DM4
Lys-Nε-SPDB-DM4 |
||
Lys-Nε-SPDB-DM4 is a drug-linker conjugate composed of a potent a tubulin inhibitor DM4 and a linker Lys-Nε-SPDB to make antibody drug conjugate (ADC). |