Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00483 |
DFF45 Protein, Human, Recombinant (His)
DNA Fragmentation Factor Subunit Alpha,DFF45,H13,ICAD,DF... |
Human | E. coli |
DNA Fragmentation Factor Subunit Alpha (DFFA). DFFA exists as a heterodimer (DFF) with DFFB. DFF is activated once DFFA is cleaved by Caspase-3. The cleaved fragments of DFFA detach from DFFB (the active component of DFF), which in turn triggers DNA fragmentation as well as chromatin condensation during apoptosis. A reduced level of DFFA detected in ovarian endometriosis may be a part of an apoptosis-resistant mechanism enhancing the disease progression. |