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Cat. No. | Product Name | Target | Signaling Pathways |
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T8418 |
DCLK1-IN-1
|
Others | Others |
DCLK1-IN-1 是选择性的、体内相容的双皮质素样激酶1DCLK1激酶结构域化学探针。它抑制 DCLK1 和 DCLK2 激酶。它具有低毒性,可以研究 DCLK1 的生物学特性,确定其在肿瘤中的作用,如 DCLK1+胰腺导管腺癌。 | |||
T79421 |
DCLK1-IN-2
|
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DCLK1-IN-2(化合物I-5)为高效DCLK1抑制剂,IC50值为171.3 nM。对SW1990细胞系具有明显的抗增殖活性(IC50为0.6 μM),并展现出体内的抗肿瘤效能。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-04752 |
DCLK1 Protein, Human, Recombinant
doublecortin-like kinase 1,CL1,DCLK,CLICK1,DCAMKL1,... |
Human | Baculovirus-Insect Cells |
DCAMKL1, also known as DCLK1, is a member of the protein kinase superfamily and the doublecortin family. It contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. DCA... | |||
TMPY-04404 |
DCLK1 Protein, Human, Recombinant (aa 1-705, His & GST)
doublecortin-like kinase 1,CL1,DCDC3A,DCLK,CLICK1,D... |
Human | Baculovirus-Insect Cells |
DCAMKL1, also known as DCLK1, is a member of the protein kinase superfamily and the doublecortin family. It contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. DCA... |