Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP2068 |
Cyclotraxin B
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Antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also shown to exhibit putative anxiolytic p | |||
TP2068L |
Cyclotraxin B acetate(1203586-72-4 free base)
|
Trk receptor | Tyrosine Kinase/Adaptors |
Cyclotraxin B acetate(1203586-72-4 free base) 是 TrkB 受体的拮抗剂;抑制 BDNF 诱导的 TrkB 活性 (IC50 = 0.30 nM)。变构改变 TrkB 受体构象但不改变 BDNF 结合。防止 BDNF 引起的小鼠冷异常性疼痛。还显示在小鼠中表现出推定的抗焦虑特性。 | |||
T75832 |
Cyclotraxin B TFA
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Cyclotraxin B TFA 是一种环肽,是一种高效且选择性的 TrkB 抑制剂,且不会改变 BDNF 的结合。Cyclotraxin B TFA 非竞争性地抑制 BDNF 诱导的 TrkB 活性,IC50值为 0.30 nM。Cyclotraxin B TFA 可以穿越血脑屏障,并具有止痛和抗焦虑的行为作用。 |