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4

抑制剂 & 化合物

2

天然产物

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Cat. No. Product Name Target Signaling Pathways
T41103 Compound 48/80

Poly-p-methoxyphenethylmethylamine

Compound 48/80, also known as Poly-p-methoxyphenethylmethylamine, is a commonly utilized mast cell activator in animal and tissue models. This compound exerts its effect by stimulating trimeric G-proteins at the mast cell membrane, triggering degranulation through both phospholipase C and D pathways.
T13623 Compound 48/80 trihydrochloride

C48/80 trihydrochloride

Phospholipase Metabolism
Compound 48/80 trihydrochloride (C48/80 trihydrochloride) 是 N-甲基对甲氧基苯乙胺和甲醛发生缩合反应后的混合物。Compound 48/80 trihydrochloride 是一种肥大细胞 (mast cell) 脱颗粒剂和组胺 (histamine) 释放剂。Compound 48/80 trihydrochloride 对人血小板磷脂酰肌醇特异性磷脂酶 C (phosphatidylinositol-specific phospholipase C) 活性有抑制作用。
TP1946 QWF

Tripeptide substance P (SP) antagonist (IC50 = 90 μM). Also inhibits binding of SP to Mas-related GPCR (MRGPR) X2. Inhibits SP-induced IgE-independent degranulation of mast cells in vitro. Inhibits compound 48/80-induced MRGPRX2 activation and scratching
T62132 S-777469

S-777469 是一种选择性的、口服具有活力的大麻素 2 型受体(CB2)激动剂 (Ki: 36 nM)。S-777469 能够剂量依赖性地明显抑制化合物 48/80 诱导的小鼠抓挠行为。S-777469 兴奋 CB2,抑制瘙痒信号的传递,显示出止痒效果。

化合物

Compound 48/80
Cat.No: T41103
Synonym: Poly-p-methoxyphenethylmethylamine
Target:
Compound 48/80 trihydrochloride
Cat.No: T13623
Synonym: C48/80 trihydrochloride
Target: Phospholipase
QWF
Cat.No: TP1946
Synonym:
Target:
S-777469
Cat.No: T62132
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
TN5647 Confluentin

Confluentin has antimicrobial activity against the gram-positive bacteria.Confluentin significantly inhibits compound 48/80-induced histamine release from rat peritoneal mast cells. Confluentin also shows weak cytotoxicity against four human tumor cell li
TN1623 Escin IIB

Others; NOS Immunology/Inflammation; Others
Escin IIB has positive effects on acute inflammation in animals, it can inhibit the induced by serotonin in rats, the hind paw edema induced by carrageenin, and the scratching behavior induced by compound 48/80 in mice.

天然产物

Confluentin
Cat.No: TN5647
Synonym:
Target:
Escin IIB
Cat.No: TN1623
Synonym:
Target: Others, NOS
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