Cat. No. | Product Name | Target | Signaling Pathways |
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T61009 | Complex III-IN-1 | ||
Complex III-IN-1 (Compd 4c-2) 是 complex III 的抑制剂,具有抗真菌活性。Complex III-IN-1 对核盘菌的EC50值为 18.53 mg/L。 | |||
T60949 | Complex III-IN-2 | ||
Complex III-IN-2 (Compd 4d-2) 是complex III 的抑制剂,具有抗真菌活性,其对植物病菌立枯病菌和核盘菌的EC50值分别为29.31 mg/L 和 29.98 mg/L。 | |||
T76025 |
Urocortin III, mouse TFA
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Urocortin III, mouse TFA是CRF(促肾上腺皮质激素释放因子)相关的肽。该化合物主要通过结合并激活CRF-R2发挥作用。Urocortin III(Ucn3)是已知参与调节行为压力反应体系的组分之一。它和CRF-R2在大脑杏仁核中共同作用,从而参与调控复杂的社会动力学行为。 | |||
T74681 | NecroIr2 | ||
NecroIr2 是一种铱 (III) 复合物,是顺铂 (Cisplatin) 耐药肺癌细胞 (A549R) 的坏死诱导剂。NecroIr2 选择性积累在线粒体中,导致氧化应激和线粒体膜电位 (MMP) 的损失。NecroIr2 能够激活受体相互作用的丝氨酸苏氨酸激酶 3 (RIPK3) 和混合谱系激酶结构域样假激酶 (MLKL),调节CDK4表达。 | |||
T74680 | NecroIr1 | ||
NecroIr1 是一种铱 (III) 复合物,是顺铂 (Cisplatin) 耐药肺癌细胞 (A549R) 的坏死诱导剂。NecroIr1 选择性积累在线粒体中,导致氧化应激和线粒体膜电位 (MMP) 的损失。NecroIr1 能够激活受体相互作用的丝氨酸苏氨酸激酶 3 (RIPK3) 和混合谱系激酶结构域样假激酶 (MLKL),调节CDK4表达。 | |||
T79743 |
Caspase-3 activator 1
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Pyroptosis | Apoptosis; Immunology/Inflammation |
Caspase-3 activator 1 (compound 4b) 是一种Ru(III)金属复合物,它能够有效抑制胃肿瘤细胞的生长与转移。该化合物通过介导caspase-3的活化而促进GSDME的裂解,产生GSDME-N末端,导致胃肿瘤细胞发生膜穿孔。Caspase-3 activator 1还能诱导焦亡及其引发的免疫应答,并可与地西他滨(DCT)构建成4b-DCT-Lip脂质纳米粒子,用于高效药物递送。 | |||
T37851 |
Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III)
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Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) is an inducer of ferroptosis.1 It induces ferroptosis, but not apoptosis or necroptosis, in NB1 cancer cells when used at a concentration of 3 μM.1 Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) inhibits proliferation of BJAB, NALM-6, Jurkat, MelHO, and MCF-7 cancer cells (IC50s = 0.07, 2.5, 1.5, 3, and 5 μM, respectively), as well as NALM-6 cells resistant to daunorubicin and vincristine when used at concentrations ranging... | |||
T83865 |
HP661
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HP661是一种针对线粒体复合物I(也称为NADH脱氢酶)的抑制剂,对复合物I具有选择性,以1 µM的浓度抑制其77.6%,而对复合物III抑制率为28.1%,对复合物II和IV则无抑制作用。HP661特异性降低具有高水平氧化磷酸化作用的人类肺癌细胞H460、NCI H441及对trametinib耐药的A549细胞的生存能力(IC50分别为10.6、29.7和15.1 nM),相较于氧化磷酸化水平低的NCI H358人类肺癌细胞(IC50 >10,000 nM)以及非癌性人类胰腺正常上皮细胞(HPNE)和MRC-5人类胎肺成纤维细胞(两者的IC50均>10,000 nM)。当以每天两次,每次30 mg/kg的剂量给药时,HP661在H460小鼠异种移植模型中减少肿瘤体积,并对trametinib引导的肿瘤生长减少产生加成效应。 | |||
T35687 |
Collismycin A
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Collismycin A is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities, including antibacterial, antiproliferative, and neuroprotective properties. It is active against a variety of bacteria (MICs = 6.25 and 100 μg/ml) and fungi (MICs = 12.5-100 μg/ml). It inhibits proliferation of A549 lung, HCT116 colon, and HeLa cervical cancer cells (IC50s = 0.3, 0.6, and 0.3 μM, respectively) and NIH373 fibroblasts (IC50 = 56.6 μM) but not MDA-MD-231 breast canc... |