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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T31857 |
Fosbretabulin [free base]
Fosbretabulin,Combretastatin A-4,CA4DP |
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Fosbretabulin is a natural cis-stilbene that interferes with cellular tubulin dynamics and selectively destroys tumor blood vessels. | |||
T32127 |
HYS-32
HYS 32 |
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HYS-32, as an analog of combretastatin A-4, can exert by enhancing connexin43 expression. | |||
T60823 | isoCA-4 | ||
isoCA-4 是一种 Combretastatin A4 的衍生物。 isoCA-4 是一种微管蛋白聚合抑制剂, 具有抗增殖活性。 | |||
T35251 |
YK-5-252
YK 5 252,YK5-252,YK-5252 |
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YK-5-252 is a dual action combretastatin A-4 (CA-4) prodrug which releases CA-4 through a disulfide bond cleavage mechanism and contains a near-infrared (NIR) fluorophore. | |||
T68400 | STA-9584 | ||
STA-9584 is a potent vascular disrupting agent, which exhibits potent antitumor activity by selectively targeting microvasculature at both the center and periphery of tumors. In vitro, 2-methoxy-5-(5-(3,4,5-trimethoxyphenyl)isoxazol-4-yl)aniline (STA-9122) (active metabolite of STA-9584 ) displayed increased potency relative to other tubulin-binding agents and was highly cytotoxic to tumor cells. STA-9584 induced significant tumor regressions in prostate and breast xenograft models in vivo and, ... | |||
T16386 |
Ombrabulin hydrochloride
AVE8062 (hydrochloride),AC7700 (hydrochloride) |
Microtubule Associated | Cytoskeletal Signaling |
Ombrabulin hydrochloride 是一种合成的、具有选择性的 CA-4 磷酸酯或 Ombrabulin 的衍生物,能破坏内皮细胞的微管蛋白细胞骨架,具有抗血管作用。Ombrabulin 是是一种微管蛋白聚合抑制剂,是 combretastatin a -4化合物类的一员,是一种水溶性的微管蛋白解聚肿瘤血管破坏化合物。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6212 |
Combretastatin A4
CA4,康普瑞汀,Z)-3,4,5,4',-四甲氧基-3'-羟基二苯乙烯,CRC 87-09 |
Microtubule Associated | Cytoskeletal Signaling |
Combretastatin A4 (CA4) 是一种微管靶向剂,可结合 β-tubulin,Kd 值为 0.4 μM。 |