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Cat. No.	Product Name	Target	Signaling Pathways
T37356	Cbl-b-IN-1	Others	Others
	Cbl-b-IN-1 是一种有效的 Cbl-b 抑制剂（IC50 <100 nM），具有潜在的抗癌活性，可用于研究肠道炎症。
T63790	Cbl-b-IN-3	E1/E2/E3 Enzyme	Ubiquitination
	Cbl-b-IN-3是一种有效的casitas b 系淋巴瘤原癌基因-b (Cbl-b)抑制剂（ic50 < 1 nM）。Cbl-b 是一种环型E3泛素蛋白连接酶，与T 淋巴细胞激活阈值的设定有关。Cbl-b 以不依赖于蛋白水解的方式负调控p85，通过其E3泛素连接酶活性，参与了p85向CD28和T 细胞抗原受体ζ的募集，抑制PI3K 抑制了Cblb-/- t 细胞活化的增强。
T79893	Cbl-b-IN-6	E1/E2/E3 Enzyme	Ubiquitination
	Cbl-b-IN-6 (Compound 246)，作为casitas B系淋巴瘤（Cbl-b）和c-Cbl的抑制剂，其IC50值分别为5.8 nM和4.4 nM。
T79895	Cbl-b-IN-8	E1/E2/E3 Enzyme	Ubiquitination
	Cbl-b-IN-8 (Compound 293)，一种casitas B系淋巴瘤（Cbl-b）及c-Cbl的抑制剂，其IC50值分别为5.5 nM和7.8 nM。
T79894	Cbl-b-IN-7	E1/E2/E3 Enzyme	Ubiquitination
	Cbl-b-IN-7 (Compound 248)作为针对casitas B系淋巴瘤(Cbl-b)和c-Cbl的抑制剂，其IC50值分别为6.7 nM与5.2 nM。
T79897	Cbl-b-IN-10	E1/E2/E3 Enzyme	Ubiquitination
	Cbl-b-IN-10（Compound 463）为针对casitas B系淋巴瘤（Cbl-b）和c-Cbl的抑制剂，其IC50值分别为6.0 nM和3.5 nM。
T79898	Cbl-b-IN-11	E1/E2/E3 Enzyme	Ubiquitination
	Cbl-b-IN-11 (Compound 466)作为casitas B系淋巴瘤 (Cbl-b) 及c-Cbl的抑制剂，显示出对Cbl-b和c-Cbl的高度选择性，其IC50值分别为6.4 nM 和6.1 nM。
T79899	Cbl-b-IN-12	E1/E2/E3 Enzyme	Ubiquitination
	Cbl-b-IN-12 (Example 10)为casitas B系淋巴瘤（CBL-B）抑制剂，IC50值<100 nM。
T79896	Cbl-b-IN-9	E1/E2/E3 Enzyme	Ubiquitination
	Cbl-b-IN-9（Compound 300）为针对casitas B系淋巴瘤（Cbl-b）及c-Cbl的抑制剂，其IC50值分别为5.6 nM与4.7 nM。
T79900	Cbl-b-IN-13	E1/E2/E3 Enzyme	Ubiquitination
	Cbl-b-IN-13 (Example 520)是一种有效的Cbl-b抑制剂，显示出<100 nM的IC50值，并能够激活T细胞。
T37468	Siamycin I
	Siamycin I is a tricyclic peptide originally isolated from Streptomyces and has antiviral and antibacterial activities. It is active against laboratory strains and clinical isolates of HIV-1 (ED50s = 0.05-0.45 and 0.89-5.7 μM, respectively), as well as the CBL-20 strain of HIV-2 (ED50 = 0.45 μM), in vitro. Siamycin I inhibits HIV-induced fusion of C8166 T cells with HIV-1-infected CEM-SS cells with an ED50 value of 0.08 μM. It is also active against B. subtilis, M. luteus, and S. aureus (MICs = ...