Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10680 |
Carebastine
|
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Carebastine 是 Ebastine 的活性代谢产物,可抑制巨噬细胞移动抑制因子的表达。它是组胺 H1 受体拮抗剂,可抑制 VEGF 诱导的 HUVEC 和 HPAEC 增殖,迁移和血管生成。 | |||
T37515 |
Hydroxy Ebastine
|
||
Hydroxy Ebastine is an ebastine metabolite. Ebastine undergoes rapid first-pass metabolism by the cytochrome P450 isoform CYP2J2 to form hydroxy ebastine which is then metabolized by CYP2J2 and CYP3A4 to form carebastine. |