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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10715 |
CCR6 inhibitor 1
|
CCR | Immunology/Inflammation; Microbiology/Virology |
CCR6 inhibitor 1是一种有效的选择性CCR6抑制剂(猴子和人类CCR6的IC50分别为0.45和6 nM)。CCR6在自身免疫性疾病和非自身免疫性疾病中都有关联,因此CCR6 inhibitor 1 作为CCR6的小分子抑制剂对体外和体内病理生理学研究都有用。 | |||
T60145 |
CCR6 antagonist 1
|
CCR | Immunology/Inflammation; Microbiology/Virology |
CCR6 antagonist 1 是一种 CCR6 拮抗剂,可抑制 CCL20/CCR6 信号通路。 CCR6 antagonist 1 可用于自身免疫介导的炎症性疾病的研究,如炎症性肠病 (IBDs)。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00711 |
GADD45G Protein, Human, Recombinant (His)
Cytokine-Responsive Protein CR6,Growth Arr... |
Human | E. coli |
Growth Arrest and DNA Damage-Inducible Protein GADD45 Υ (GADD45G) is a nuclear protein which belongs to the GADD45 family. GADD45G is highly expressed in placenta. GADD45G interacts with various proteins whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. GADD45G responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. GADD45G is also involved in the regulation of growth and apo... | |||
TMPY-03655 |
GADD45G Protein, Human, Recombinant
GADD45γ,growth arrest and DNA-damage-inducible, γ,DDIT2,grow... |
Human | E. coli |
GADD45G, also known as CR6, is part of the nuclear proteins to interact with various proteins whose transcript levels are raised after stressful growth arrest conditions and treatment with DNA-damaging agents. GADD45G reacts to environmental stresses by mediating activation of the p38/JNK pathway which is mediated through their protein binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. GADD45G acts as a new-age tumor suppressor however is being fr... | |||
TMPH-01066 |
CCR6 Protein, Human, Recombinant (His & Myc)
GPRCY4,Chemokine receptor-like 3,C-C chemokine receptor type... |
Human | E. coli |
CCR6 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 12.9 kDa and the accession number is P51684. |