Cat. No. | Product Name | Target | Signaling Pathways |
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T0373L1 |
Erlotinib mesylate
CP-358774,CP-358,774,埃罗替尼甲磺酸盐,OSI-774,CP358774,OSI 774 |
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Erlotinib is an epidermal growth factor receptor inhibitor. Erlotinib binds in a reversible fashion to the adenosine triphosphate (ATP) binding site of the receptor. | |||
T35915 |
Erlotinib-13C6
Erlotinib-13C6 |
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Erlotinib-13C6 (CP-358774-13C6) is a 13C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1]. Erlotinib reduces EGFR autophosphorylation in intact tumor cells with an IC50 of 20 nM. Erlotinib is used for the treatment of non-small cell lung cancer[1].Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process[2]... |