Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T17036 |
Tenidap
CP-66248 |
COX | Immunology/Inflammation; Neuroscience |
Tenidap is a non-steroidal anti-inflammatory drug and is a selective COX-1 inhibitor (IC50: 0.03 µM and 1.2 µM for COX-1 and COX-2, respectively). Tenidap is also a specific SLC26A3 inhibitor. | |||
T71262 |
AZD-8418
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AZD-8418 is an mGlu2 receptor positive allosteric modulators that attenuates nicotine-taking and nicotine-seeking behavior. Acute treatment with AZD8418 (0.37, 1.12, 3.73, 7.46, and 14.92 mg/kg) and AZD8529 (1.75, 5.83, 17.5, and 58.3 mg/kg) deceased nicotine self-administration and had no effect on food-maintained responding. Chronic treatment with AZD8418 attenuated nicotine self-administration, but tolerance to this effect developed quickly. The inhibition of nicotine self-administration by c... |