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Search Results for " cfi "

Targets Recommended: PLK

9

抑制剂 & 化合物

9

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T22288	(1E)-CFI-400437 dihydrochloride CFI-400437 dihydrochloride	PLK	Cell Cycle/Checkpoint
	(1E)-CFI-400437 dihydrochloride (CFI-400437 dihydrochloride) 是一种选择性和有效的 polo 样激酶 4 (PLK4) 抑制剂，IC50为 0.6 nM。它还抑制 Aurora A、 Aurora B、 KDR 和 FLT-3，IC50分别为 0.37、0.21、0.48 和 0.18 μM，具有抗增殖活性。
T22289	CFI-402257	Kinesin	Cytoskeletal Signaling
	CFI-402257 是 Mps1/TTK 激酶的选择性抑制剂（Mps1 Ki = 0.09 nM；EC50 = 6.5 nM），可用于肝细胞癌疾病的研究。
T7384	Ocifisertib（CFI-400945 free base）	PLK	Cell Cycle/Checkpoint
	CFI-400945 是一种有效的、选择性的、具有口服活性的 polo 样激酶 4（PLK4；Ki 值为 0.26 nM）的抑制剂。
T30804	CFI-401870 CFI 401870
	CFI-401870 is an orally bioavailable potent tyrosine threonine kinase (TTK) inhibitor.
T70940	CFI-400936
	CFI-400936 is a potent and selective TTK inhibitor with potential anticancer activity. This potent inhibitor of TTK (IC50=3.6nM) demonstrated good activity in cell based assay and selectivity against a panel of human kinases.
T30805	CFI-401980
	CFI-401980 is a potent and selective, novel class of TTK inhibitor.
T22645	CFI-400945	Others	Others
	CFI-400945 is an orally active, potent, and selective inhibitor of polo-like kinase 4.
T63318	CFI-400437
	CFI-400437 是一种ATP 竞争性的PLK4抑制剂 (IC50: 0.6 nM)，是一种吲哚醌衍生物。
T70938	SN00799639
	SN00799639, also known as SN639, is a potent inhibitor of the motility and development of parasitic larvae of Haemonchus contortus, a blood-feeding parasitic nematode of major economic importance in ruminants. SN639 displayed lower potency, with IC50 values of 8.4 μM (xL3 motility) and 0.29 μM (L4 development).

化合物

(1E)-CFI-400437 dihydrochloride

Cat.No: T22288

Synonym: CFI-400437 dihydrochloride

Target: PLK

Cat.No: T22289

Target: Kinesin

Ocifisertib（CFI-400945 free base）

Cat.No: T7384

Target: PLK

Cat.No: T30804

Synonym: CFI 401870

Cat.No: T70940

Cat.No: T30805

Cat.No: T22645

Target: Others

Cat.No: T63318

Cat.No: T70938

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-06976	CFI Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	CFI Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 66.75 kDa and the accession number is Q61129.
TMPH-03273	Complement factor I Protein, Rat, Recombinant (His & Myc) If,Complement factor I,Cfi,C3B/C4B inactivator	Rat	Baculovirus Insect Cells
	Complement factor I Protein, Rat, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 69.2 kDa and the accession number is Q9WUW3.
TMPK-01023	Complement factor I Protein, Mouse, Recombinant (His) FIC3b-INA,I factor (complement),IF,C3B/C4B inactivator,C3BIN...	Mouse	HEK293 Cells
	Complement factor I (CFI) is a serine protease which plays a key role in the modulation of complement system and the induced-fit factor responsible for controlling the complement-mediated processes. Complement factor I Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 66.39 kDa and the accession number is Q61129.
TMPK-00776	Complement factor I Protein, Human, Recombinant (His) FIC3b-INA,KAF,IF,CFI,I factor (complement),EC:3.4.2...	Human	HEK293 Cells
	Complement factor I (CFI) is a serine protease which plays a key role in the modulation of complement system and the induced-fit factor responsible for controlling the complement-mediated processes. Complement factor I Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 64.58 kDa and the accession number is P05156.
TMPY-06207	Human metapneumovirus (strain HMPV/Homo sapiens/PER/CFI0320/2010/A) glycoprotein G Protein (His)	HMPV	HEK293 Cells
	Human metapneumovirus (strain HMPV/Homo sapiens/PER/CFI0320/2010/A) glycoprotein G Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.4 kDa and the accession number is X4XYT2.
TMPY-06206	Human metapneumovirus (strain HMPV/Homo sapiens/PER/CFI0466/2010/B) glycoprotein G Protein (His)	HMPV	HEK293 Cells
	Human metapneumovirus (strain HMPV/Homo sapiens/PER/CFI0466/2010/B) glycoprotein G Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.6 kDa and the accession number is X4Y8Q3.
TMPH-02845	Properdin Protein, Mouse, Recombinant (His & Myc)	Mouse	HEK293 Cells
	A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Inhibits CFI-CFH mediated degradation of Inhibits CFI-CFH mediated degradation of Complement C3 beta chain (C3b).
TMPH-02844	Properdin Protein, Mouse, Recombinant (His)	Mouse	E. coli
	A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Inhibits CFI-CFH mediated degradation of Inhibits CFI-CFH mediated degradation of Complement C3 beta chain (C3b).
TMPH-03038	Cobra venom factor Protein, Naja kaouthia, Recombinant (His & SUMO) Cobra venom factor,Complement C3 homolog,CVFk,CVF	Naja kaouthia	E. coli
	Complement-activating protein in cobra venom. It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex CVF/Bb. CVF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, CVF/Bb is a stable complex and completely re...

重组蛋白

CFI Protein, Mouse, Recombinant (His)

Cat.No: TMPY-06976

Species: Mouse

Expression System: HEK293 Cells

Complement factor I Protein, Rat, Recombinant (His & Myc)

Cat.No: TMPH-03273

Species: Rat

Expression System: Baculovirus Insect Cells

Complement factor I Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01023

Species: Mouse

Expression System: HEK293 Cells

Complement factor I Protein, Human, Recombinant (His)

Cat.No: TMPK-00776

Species: Human

Expression System: HEK293 Cells

Human metapneumovirus (strain HMPV/Homo sapiens/PER/CFI0320/2010/A) glycoprotein G Protein (His)

Cat.No: TMPY-06207

Species: HMPV

Expression System: HEK293 Cells

Human metapneumovirus (strain HMPV/Homo sapiens/PER/CFI0466/2010/B) glycoprotein G Protein (His)

Cat.No: TMPY-06206

Species: HMPV

Expression System: HEK293 Cells

Properdin Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02845

Species: Mouse

Expression System: HEK293 Cells

Properdin Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02844

Species: Mouse

Expression System: E. coli

Cobra venom factor Protein, Naja kaouthia, Recombinant (His & SUMO)

Cat.No: TMPH-03038

Species: Naja kaouthia

Expression System: E. coli

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