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Cat. No. Product Name Target Signaling Pathways
T40263 CDK5-IN-1

CDK5-IN-1

CDK5-IN-1 is a highly potent inhibitor of CDK5, displaying an inhibitory activity of less than 10 nM. This potent compound is specifically employed in scientific investigations relating to kidney diseases.
T35555 GSK-3/CDK5/CDK2-IN-1

GSK-3/CDK5/CDK2-IN-1

GSK-3/CDK5/CDK2-IN-1 is an imidazole derivative compound that inhibits cdk5, cdk2, and GSK-3.it has demonstrated applications in cancer research and the study of neurodegenerative diseases [1].
T71549 RKS-262

RKS262 is a specific cyclin/CDK inhibitor. RKS262 was identified by structural optimization of Nifurtimox which is currently undergoing phase II clinical trials to treat high-risk neuroblastoma. In a NCI(60) cell-line assay RKS262 exhibited significant cytotoxicity in ovarian cancer cells and a variety of other cell lines exceeding effects of commercial drugs such as cisplatin, 5-FU, cyclophosphamide or sapacitabine. Various leukemia cell-lines were most sensitive (GI(50): ~ 10 nM) while several...

化合物

CDK5-IN-1
Cat.No: T40263
Synonym: CDK5-IN-1
Target:
GSK-3/CDK5/CDK2-IN-1
Cat.No: T35555
Synonym: GSK-3/CDK5/CDK2-IN-1
Target:
RKS-262
Cat.No: T71549
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T38441 Manzamine A hydrochloride

Manzamine A hydrochloride is an orally active beta-carboline alkaloid that exhibits specific inhibitory effects on GSK-3β (IC50 = 10.2 μM) and CDK-5 (IC50 = 1.5 μM). Additionally, it targets vacuolar ATPases, leading to the inhibition of autophagy in pancreatic cancer cells. Manzamine A hydrochloride possesses antimalarial and anticancer properties, and also demonstrates potent activity against HSV-1[4].

天然产物

Manzamine A hydrochloride
Cat.No: T38441
Synonym:
Target:
TargetMol Loading
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