搜索结果

Search Results for " cdk-2-in-7 "

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T40160	CDK2-IN-7 CDK2-IN-7
	CDK2-IN-7 is a CDK2 inhibitor for treating cancer ( IC 50 < 50 nM).
T39864	CDK7-IN-2 hydrochloride hydrate CDK7-IN-2 hydrochloride hydrate
	CDK7-IN-2 hydrochloride hydrate (Example 6) is a highly effective and specific inhibitor of the CDK7 enzyme. This compound exhibits significant anti-cancer properties.
T79729	EGFR/CDK2-IN-4	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EGFR/CDK2-IN-4（化合物4c）是一种EGFR与CDK-2的双重抑制剂，其IC50值分别为89.6 nM和165.4 nM。该化合物在MCF-7细胞中能诱导(apoptosis)凋亡，并导致细胞周期在S期停滞。EGFR/CDK2-IN-4显示出显著的抗癌细胞毒性，对MCF-7细胞的IC50为2.74 μM。
T79727	EGFR/CDK2-IN-2	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EGFR/CDK2-IN-2（compound 6a）是一种针对EGFR和CDK-2的双重抑制剂，具有19.6 nM和87.9 nM的IC50s。该化合物能在MCF-7细胞内诱导凋亡，并在S期引发细胞周期停滞。此外，EGFR/CDK2-IN-2展现出IC50为0.39 μM的显著抗癌活性，对MCF-7细胞具有强效的细胞毒性。
T79728	EGFR/CDK2-IN-3	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EGFR/CDK2-IN-3（compound 4b）是一种针对EGFR与CDK-2的双重抑制剂，分别具有71.7 nM和113.7 nM的IC50s。该化合物在MCF-7细胞中能诱导凋亡，导致细胞周期在S期停滞，并显示出对癌细胞的明显毒性，其对MCF-7细胞的IC50值为3.16 μM。
T72951	CDK4/6-IN-14
	CDK4/6-IN-14 是一种有效且高度选择性的 CDK4和 CDK6(CDK) 抑制剂，IC50分别为 10 nM 和 16 nM。CDK4/6-IN-14 的选择性是 CDK1、2、7 和 9 的 60 多倍，并且在其他 205 种激酶中表现出高选择性。
T36409	Roccellic Acid
	Roccellic acid is a lichen secondary metabolite that has been found in R. montagnei and has antibacterial and anticancer activities.1,2 It is active against the bacteria S. gordonii and P. gingivalis (MIC = 46.9 μg/ml for both).1 Roccellic acid (100 μg/ml) inhibits proliferation of MDA-MB-231, MCF-7, and DLD-1 cancer cells by 65.3, 75.8, and 87.9%, respectively.2 \|1. Sweidan, A., Chollet-Krugler, M., Sauvager, A., et al. Antibacterial activities of natural lichen compounds against Streptococcus ...
T37065	6-Chloro-2-fluoropurine
	6-Chloro-2-fluoropurine is a heterocyclic building block.1,2It has been used in the synthesis of purine nucleosides that inhibit cyclin-dependent kinases (CDKs)in vitro.16-Chloro-2-fluoropurine has also been used in the synthesis of purine nucleosides that are active against HIV-1 and hepatitis B virus (HBV)in vitro.2 1.Wilson, S.C., Atrash, B., Barlow, C., et al.Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitorsBioorg. Med. Chem.19(22)6949-6965(2011) 2....