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Cat. No. Product Name Target Signaling Pathways
T78327 Domvanalimab

AB154
Domvanalimab (AB154)是一种针对TIGIT的人源化单克隆抗体，能够特异性结合人类TIGIT9，并有效阻断TIGIT与CD155的相互作用，常用于癌症相关的研究领域。
T82436 Etigilimab

OMP-313M32
Etigilimab (OMP-313M32) 为人源化IgG1单克隆抗体，旨在阻断TIGIT与PVR (CD155；脊髓灰质炎病毒受体)间的结合，进而抑制信号传导，通过诱导靶细胞凋亡实现其作用。
T82609 Dargistotug

M-6223
Dargistotug (M-6223) 是一种靶向 TIGIT 的全人 IgG1 类型单克隆抗体。TIGIT 是一种带有 Ig 结构域和 ITIM 的 T 细胞免疫受体，充当抑制性免疫检查点。Dargistotug 通过与 CD155 等分子结合抑制 NK 细胞活性，减少细胞因子分泌，并能直接或间接地抑制效应 T 细胞活性和上调 Tregs，从而发挥免疫抑制作用。

化合物

Domvanalimab
Cat.No: T78327
Synonym: AB154
Target:
Etigilimab
Cat.No: T82436
Synonym: OMP-313M32
Target:
Dargistotug
Cat.No: T82609
Synonym: M-6223
Target:
Species：
Human (8)
Mouse (3)
Cynomolgus (1)
Rat (1)
Rhesus (1)
Expression System：
HEK293 Cells (14)
Tag：
C-His-Avi (3)
C-6xHis (2)
C-His (2)
His (2)
hFc, Avi (2)
C-hFc (1)
C-mFc (1)
His, Avi (1)
Cat. No. Product Name Species Expression System
TMPJ-00651 CD155/PVR Protein, Human, Recombinant (aa 21-343, His)

Poliovirus Receptor,PVS,Nectin-Like Protein 5,NECL-5,CD<...

 Human HEK293 Cells
Poliovirus Receptor (PVR) is a 70 kDa type I transmembrane single-span glycoprotein that belongs to the nectin-like (Necl) family and was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. PVR contains three Ig-like extracellular domains, a transmembrane segment, and a cytoplasmic tail. The normal cellular function of PVR maybe the involvement of intercellular adhension be...
TMPY-00699 CD155/PVR Protein, Human, Recombinant (hFc)

poliovirus receptor,NECL5,HVED,PVS,Necl-5,TAGE4,CD<...

 Human HEK293 Cells
CD155/PVR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.8 kDa and the accession number is P15151-1.
TMPY-01386 CD155/PVR Protein, Human, Recombinant (His)

NECL5,TAGE4,PVS,CD155,HVED,Necl-5,poliovir...

 Human HEK293 Cells
CD155/PVR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.5 kDa and the accession number is P15151-1.
TMPY-05791 CD155/PVR Protein, Mouse, Recombinant (mFc)

Taa1,3830421F03Rik,poliovirus receptor,necl-5,D7Ertd458e,HVE...

 Mouse HEK293 Cells
CD155/PVR Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 60.78 kDa and the accession number is Q8K094.
TMPY-05596 CD155/PVR Protein, Human, Recombinant (His & Avi), Biotinylated

NECL5,Necl-5,TAGE4,HVED,CD155,PVS,poliovir...

 Human HEK293 Cells
CD155/PVR Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 38.3 kDa and the accession number is P15151.2.
TMPY-01612 CD155/PVR Protein, Rhesus, Recombinant (His)

poliovirus receptor

 Rhesus HEK293 Cells
CD155/PVR Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35.8 kDa and the accession number is Q0MSE6.
TMPY-00762 CD155/PVR Protein, Mouse, Recombinant (His)

poliovirus receptor,D7Ertd458e,mE4,Taa1,necl-5,PVS,3830421F0...

 Mouse HEK293 Cells
CD155/PVR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28 kDa and the accession number is Q8K094.
TMPY-06133 CD155/PVR Protein, Human, Recombinant (hFc & Avi), Biotinylated

TAGE4,CD155,NECL5,poliovirus receptor,HVED...

 Human HEK293 Cells
CD155/PVR Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 63.6 kDa and the accession number is P15151-1.
TMPK-00260 CD155/PVR Protein, Human, Recombinant (His & Avi)

NECL5,PVSFLJ25946,Necl-5,CD155,Tage4,PVR,H...

 Human HEK293 Cells
CD155 is a cell surface adhesion molecule functioning in tumor cell migration, invasion, and metastasis, and not surprisingly, is also designated as a common tumor-associated antigen. CD155 is also recognized by NK cells to induce their cytotoxicity. CD155 is also commonly referred to as the "poliovirus receptor," or PVR.
TMPY-05597 CD155/PVR Protein, Mouse, Recombinant (hFc & Avi), Biotinylated

PVS,Taa1,Tage4,CD155,poliovirus receptor,m...

 Mouse HEK293 Cells
CD155/PVR Protein, Mouse, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 62.9 kDa and the accession number is Q8K094.
TMPY-01610 CD155/PVR Protein, Rat, Recombinant (His)

poliovirus receptor

 Rat HEK293 Cells
CD155/PVR Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35.8 kDa and the accession number is A6J8V8.
TMPK-00230 DNAM-1/CD226 Protein, Human, Recombinant (His & Avi), Biotinylated

CD226,PTA1,CD226 molecule,TLiSA1,DNAM1

 Human HEK293 Cells
DNAX accessory molecule-1 (DNAM-1), also known as CD226, is a 65 kDa type I transmembrane glycoprotein in the immunoglobulin superfamily.DNAM-1 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155, and cross-linking DNAM-1 with antibodies causes cellular activation. Furthermore, DNAM-1 can interact with PVR and PVRL2. DNAM-1/CD226 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weig...
TMPK-00229 DNAM-1/CD226 Protein, Human, Recombinant (His & Avi)

PTA1,TLiSA1,DNAM1,CD226,CD226 molecule

 Human HEK293 Cells
DNAX accessory molecule-1 (DNAM-1), also known as CD226, is a 65 kDa type I transmembrane glycoprotein in the immunoglobulin superfamily.DNAM-1 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155, and cross-linking DNAM-1 with antibodies causes cellular activation. Furthermore, DNAM-1 can interact with PVR and PVRL2. DNAM-1/CD226 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 28.9 kDa...
TMPJ-00629 TIGIT Protein, Cynomolgus, Recombinant (His)

VSTM3,V-set and transmembrane domain-containing protein 3,T-...

 Cynomolgus HEK293 Cells
T cell immunoreceptor with Ig and ITIM domains (TIGIT), also called VSIG9 and Vstm3, is a member of the CD28 family within the Ig superfamily of proteins. TIGIT contains an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM), and is expressed on regulatory, memory, activated T cells and NK cells. TIGIT binds to CD155(PVR) that appear on dendritic cells (DC), macrophages and endothelium with high affinity, and CD112(PVRL2) with lower...

重组蛋白

CD155/PVR Protein, Human, Recombinant (aa 21-343, His)
Cat.No: TMPJ-00651
Species: Human
Expression System: HEK293 Cells
CD155/PVR Protein, Human, Recombinant (hFc)
Cat.No: TMPY-00699
Species: Human
Expression System: HEK293 Cells
CD155/PVR Protein, Human, Recombinant (His)
Cat.No: TMPY-01386
Species: Human
Expression System: HEK293 Cells
CD155/PVR Protein, Mouse, Recombinant (mFc)
Cat.No: TMPY-05791
Species: Mouse
Expression System: HEK293 Cells
CD155/PVR Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPY-05596
Species: Human
Expression System: HEK293 Cells
CD155/PVR Protein, Rhesus, Recombinant (His)
Cat.No: TMPY-01612
Species: Rhesus
Expression System: HEK293 Cells
CD155/PVR Protein, Mouse, Recombinant (His)
Cat.No: TMPY-00762
Species: Mouse
Expression System: HEK293 Cells
CD155/PVR Protein, Human, Recombinant (hFc & Avi), Biotinylated
Cat.No: TMPY-06133
Species: Human
Expression System: HEK293 Cells
CD155/PVR Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00260
Species: Human
Expression System: HEK293 Cells
CD155/PVR Protein, Mouse, Recombinant (hFc & Avi), Biotinylated
Cat.No: TMPY-05597
Species: Mouse
Expression System: HEK293 Cells
CD155/PVR Protein, Rat, Recombinant (His)
Cat.No: TMPY-01610
Species: Rat
Expression System: HEK293 Cells
DNAM-1/CD226 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-00230
Species: Human
Expression System: HEK293 Cells
DNAM-1/CD226 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00229
Species: Human
Expression System: HEK293 Cells
TIGIT Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPJ-00629
Species: Cynomolgus
Expression System: HEK293 Cells
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