Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7080 |
CCT245737
SRA737 |
Chk | Cell Cycle/Checkpoint |
CCT245737 (SRA737) 是一种具有口服活性的选择性 Chk1 抑制剂,IC50值为 1.3 nM。 | |||
T70553 |
CCT245737(S)
|
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CCT245737(S) is a highly selective oral checkpoint kinase 1 (CHK1) inhibitor. | |||
T70552 |
Ipatasertib tosylate
|
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Ipatasertib, also known as GDC0068, is an orally active, potent and selective Akt inhibitor. GDC-0068 blocked Akt signaling both in cultured human cancer cell lines and in tumor xenograft models. Inhibition of Akt activity by GDC-0068 resulted in blockade of cell-cycle progression and reduced viability of cancer cell lines. Markers of Akt activation, including high-basal phospho-Akt levels, PTEN loss, and PIK3CA kinase domain mutations, correlate with sensitivity to GDC-0068. In multiple tumor... |