Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T28072 |
MLN-3897
AVE9897,AVE 9897,CCR1 antagonist 10,AVE-9897 |
CCR | Immunology/Inflammation; Microbiology/Virology |
MLN-3897 (CCR1 antagonist 10) 是一种具有口服活性的 CCR1 拮抗剂,对于 125I-MIP-1α 与 THP-1 细胞膜的结合,Ki 为 2.3 nM。 MLN-3897 抑制 Akt 信号转导和 MM 细胞存活和增殖。 | |||
T41016 |
Vercirnon sodium
GSK-1605786 sodium,CCX282-Bsodium,维塞诺钠盐,Traficet-ENsodium |
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Vercirnon (GSK1605786A) sodium is an orally bioavailable, selective, and potent antagonist of CCR9 . Vercirnon sodium inhibits CCR9-mediated Ca 2+ mobilization and chemotaxis on Molt-4 cells with IC 50 values of 5.4 and 3.4 nM, respectively. Vercirnon sodium is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC 50 s>10 μM for all). Vercirnon sodium is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9 (CCR9A and CCR9B) with IC 50 values of 2.8 and 2.6 nM, respectivel... |