Cat. No. | Product Name | Target | Signaling Pathways |
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T61884 |
C6 Ceramide
N-hexanoylsphingosine,N-(hexanoyl)sphing-4-enine |
Apoptosis | Apoptosis |
C6 Ceramide (N-hexanoylsphingosine) 是神经酰胺途径的一种激活剂,通过激活ERK使细胞停滞在G0/G1期,可以在多种癌细胞系中发挥作用。 | |||
T36321 |
C6 Urea Ceramide
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C6 urea ceramide is an inhibitor of neutral ceramidase.1 It increases total ceramide levels in wild-type mouse embryonic fibroblasts (MEFs) and in HT-29 colon cancer cells but not in MEFs lacking neutral ceramidase. It inhibits proliferation of, and induces apoptosis and autophagy in HT-29, but not non-cancerous RIE-1, cells when used at concentrations of 5 and 10 μM. C6 urea ceramide decreases total β-catenin, increases phosphorylated β-catenin, and induces colocalization of β-catenin with the ... | |||
T78461 |
C6 NBD Ceramide
Nbd-ceramide |
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C6 NBD Ceramide 是一种细胞膜渗透性高尔基体荧光探针(Ex=466 nm, Em=536 nm),是一种带有绿色荧光标记的神经酰胺,可识别活体及固定细胞的高尔基体,观测活细胞中高尔基体形态变化。C6 NBD Ceramide 在细胞内可代谢生成荧光鞘磷脂和葡糖基甘油酰胺,从而应用于鞘脂转运和代谢机制研究。 | |||
T36320 |
C6 L-threo Ceramide (d18:1/6:0)
C6 L-threo Ceramide (d18:1/6:0) |
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C6 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides., C6 L-threo Ceramide is cytotoxic to U937 cells in vitro (IC50 = 18 μM). It is metabolically inactive and, unlike C6 L-erythro ceramide , C6 L-threo ceramide cannot be converted to C6 glucosylceramide by ceramide glucosyltransferase. C6 L-threo Ceramide enhances IL-4 production induced by phorbol 12-myristate 13-acetate in EL4 T cells when used at a concentration of 10 μM. | |||
T37565 |
C6 D-threo Ceramide (d18:1/6:0)
C6 D-threo Ceramide (d18:1/6:0) |
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C6 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides., C6 D-threo Ceramide is cytotoxic to U937 cells in vitro (IC50 = 18 μM). It is metabolically inactive and, unlike C6 L-erythro ceramide , C6 D-threo ceramide cannot be converted to C6 glucosylceramide by ceramide glucosyltransferase. C6 D-threo Ceramide promotes survival of isolated rat spinal neurons when used at concentrations up to 2.5 μM but induces cell death at concentrations greater... | |||
T36319 |
C6 L-erythro Ceramide (d18:1/6:0)
C6 L-erythro Ceramide (d18:1/6:0) |
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C6 L-erythro Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is metabolized by ceramide glucosyltransferase to form C6 L-erythro glucosylceramide. C6 L-erythro Ceramide is cytotoxic to U937 cells (IC50 = 18 μM). |