Cat. No. | Product Name | Target | Signaling Pathways |
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T38279 |
C2-8
C2-8 |
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C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC50s = 25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively). It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isolated from R6/2 transgenic mice and reduces neurodegeneration in a dose-dependent manner in a Drosophila model of Huntington's disease. C2-8 (100 and 200 mg/kg) reduces huntingtin aggregate size, reduces neuronal atrophy, and improves motor performance in a rotarod test in the R6/2... | |||
T60078 |
NSC2805
2-(2,5-dihydroxy-4-methylphenyl)-5-methylbenzene-1,4-diol |
Others | Others |
NSC2805 是 WWP2 的抑制剂,WWP2 是一种 E3 泛素连接酶,IC50 为 0.38 μM。 NSC2805 可用于抗癌研究。 | |||
T2629 |
UNC2881
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TAM Receptor | Tyrosine Kinase/Adaptors |
UNC2881 是一种特异性Mer 激酶抑制剂,可抑制稳态的Mer 激酶磷酸化,其IC50=22 nM。 | |||
T28931 |
TC-AC28
TC AC28 |
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TC-AC28 is a novel potent and selective Brd2(2) ligand. | |||
T68804 |
LC28
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LC28 is a novel inhibitor of STAT3 signaling, suppressing survival of cisplatin-resistant ovarian cancer cells. | |||
T37461 |
EOS (d18:1/32:1/18:2)
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EOS is a ceramide found in the outer layer of the epidermis in mammals. It is comprised of an ω-hydroxy very long-chain ceramide (C28-36) esterified to the essential fatty acid linoleic acid . The consecutive regio- and stereospecific oxygenation of the linoleate portion of EOS by 12(R)-lipoxygenase (12(R)-LO) and eLOX3 is essential for the maintenance of the epidermal barrier to prevent water loss. Following oxygenation, the oxidized linoleate is hydrolyzed, leaving the ω-hydroxy end of the ver... |