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Cat. No. Product Name Target Signaling Pathways
T38279 C2-8

C2-8

C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC50s = 25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively). It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isolated from R6/2 transgenic mice and reduces neurodegeneration in a dose-dependent manner in a Drosophila model of Huntington's disease. C2-8 (100 and 200 mg/kg) reduces huntingtin aggregate size, reduces neuronal atrophy, and improves motor performance in a rotarod test in the R6/2...
T17916 Pomalidomide-PEG4-C2-NH2

Cereblon Ligand-Linker Conjugates 8,E3 Ligase Ligand-Linker Conjugates 22

Others; Ligand for E3 Ligase Others; PROTAC
Pomalidomide-PEG4-C2-NH2 (E3 Ligase Ligand-Linker Conjugates 22) 是一种合成的 E3 连接酶配体- linker 偶联物,用于 PROTAC 技术中。
T15961 Mal-amido-PEG8-C2-acid

Others Others
Mal-amido-PEG8-C2-acid (US2018339985, example 142) is a noncleavable linker for antibody-drug conjugates (ADCs) [1].
T14892 Cbz-NH-PEG8-C2-acid

Others Others
Cbz-NH-PEG8-C2-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17882 Pomalidomide-PEG3-C2-NH2 (TFA)

Cereblon Ligand-Linker Conjugates 5 (TFA),E3 ligase Ligand-Linker Conjugates 30 (TFA),Pomalidomide-PEG3-C2-NH2 (TFA) (2093416-31-8 free base)

Others Others
Pomalidomide-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.

化合物

C2-8
Cat.No: T38279
Synonym: C2-8
Target:
Pomalidomide-PEG4-C2-NH2
Cat.No: T17916
Synonym: Cereblon Ligand-Linker Conjugates 8,E3 Ligase Ligand-Linker Conjugates 22
Target: Others, Ligand for E3 Ligase
Mal-amido-PEG8-C2-acid
Cat.No: T15961
Synonym:
Target: Others
Cbz-NH-PEG8-C2-acid
Cat.No: T14892
Synonym:
Target: Others
Pomalidomide-PEG3-C2-NH2 (TFA)
Cat.No: T17882
Synonym: Cereblon Ligand-Linker Conjugates 5 (TFA),E3 ligase Ligand-Linker Conjugates 30 (TFA),Pomalidomide-PEG3-C2-NH2 (TFA) (2093416-31-8 free base)
Target: Others
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