Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T38279 |
C2-8
C2-8 |
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C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC50s = 25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively). It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isolated from R6/2 transgenic mice and reduces neurodegeneration in a dose-dependent manner in a Drosophila model of Huntington's disease. C2-8 (100 and 200 mg/kg) reduces huntingtin aggregate size, reduces neuronal atrophy, and improves motor performance in a rotarod test in the R6/2... | |||
T17916 |
Pomalidomide-PEG4-C2-NH2
Cereblon Ligand-Linker Conjugates 8,E3 Ligase Ligand-Linker Conjugates 22 |
Others; Ligand for E3 Ligase | Others; PROTAC |
Pomalidomide-PEG4-C2-NH2 (E3 Ligase Ligand-Linker Conjugates 22) 是一种合成的 E3 连接酶配体- linker 偶联物,用于 PROTAC 技术中。 | |||
T15961 |
Mal-amido-PEG8-C2-acid
|
Others | Others |
Mal-amido-PEG8-C2-acid (US2018339985, example 142) is a noncleavable linker for antibody-drug conjugates (ADCs) [1]. | |||
T14892 |
Cbz-NH-PEG8-C2-acid
|
Others | Others |
Cbz-NH-PEG8-C2-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T17882 |
Pomalidomide-PEG3-C2-NH2 (TFA)
Cereblon Ligand-Linker Conjugates 5 (TFA),E3 ligase Ligand-Linker Conjugates 30 (TFA),Pomalidomide-PEG3-C2-NH2 (TFA) (2093416-31-8 free base) |
Others | Others |
Pomalidomide-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology. |