Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0142 |
Brinzolamide
布林佐胺,AL-4862 |
Carbonic Anhydrase | Metabolism |
Brinzolamide (AL-4862) 是一种碳酸酐酶(carbonic anhydrase)II 抑制剂(IC50:3.19 nM)。 | |||
T37403 | O-desmethyl Brinzolamide (hydrochloride) | ||
O-desmethyl Brinzolamide is an active metabolite of the carbonic anhydrase (CA) inhibitor brinzolamide .1,2It inhibits CAII and CAIV (IC50s = 0.136 and 165 nM, respectively).1 1.Huang, Q., Rui, E.Y., Cobbs, M., et al.Design, synthesis, and evaluation of NO-donor containing carbonic anhydrase inhibitors to lower intraocular pressureJ. Med. Chem.58(6)2821-2833(2015) 2.Lo Faro, A.F., Tini, A., Gottardi, M., et al.Development and validation of a fast ultra-high-performance liquid chromatography tand... | |||
T35713 | N-desethyl Brinzolamide (oxalate) | ||
N-desethyl Brinzolamide is an active metabolite of the carbonic anhydrase (CA) inhibitor brinzolamide .1It inhibits CAII and CAIV activities (IC50s = 1.28 and 128 nM, respectively). 1.Kim, C.-Y., Whittington, D.A., Chang, J.S., et al.Structural aspects of isozyme selectivity in the binding of inhibitors to carbonic anhydrases II and IVJ. Med. Chem.45(4)888-893(2002) | |||
T64241 | Brinzolamide hydrochloride | ||
Brinzolamide (AL-4862) hydrochloride 是一种碳酸酐酶 II(carbonic anhydrase II)的选择性抑制剂 (IC50: 3.2 nM)。Brinzolamide hydrochloride 能够抑制睫状体 CA-II,减少房水分泌,进而降低眼压 (IOP)。Brinzolamide hydrochloride 能够用于研究青光眼疾病。 |