Cat. No. | Product Name | Target | Signaling Pathways |
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T82911 |
Bcl-2-IN-15
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Bcl-2-IN-15 (Compound 13d)为Bcl-2抑制剂, 具有IC50为363 nM。该化合物能够抑制NCI白血病癌细胞系的增殖。 | |||
T61327 |
BRD4 Inhibitor-15
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BRD4 Inhibitor-15 (compound 13) is a highly potent and specific inhibitor of BRD4, effectively inhibiting it with an IC50 of 18 nM. By regulating the Bcl-2/Bax proteins and activating the caspase-3 signaling pathway, BRD4 Inhibitor-15 induces apoptosis of 22RV1 cells. Additionally, it effectively down-regulates the c-Myc level in 22RV1 cells. Due to its properties, BRD4 Inhibitor-15 is a valuable compound for research related to prostate cancer [1]. | |||
T79403 |
VEGFR-2-IN-36
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VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
VEGFR-2-IN-36(compound 15)是一种具有抗癌活性的VEGFR-2抑制剂(IC50:0.067 μM)和凋亡诱导剂。该化合物能够上调BAX水平和下调Bcl-2水平,对MCF-7(IC50=0.42 μM)和HepG2(IC50=0.22 μM)癌细胞展现出明显的毒性效果。 |