首页工具

登录

搜索结果

Search Results for " brd4-in-4 "

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T77339	BRD4-IN-4	Epigenetic Reader Domain	Chromatin/Epigenetic
	BRD4-IN-4 是一种具有选择性的 BRD4 抑制剂，对 BRD4 的IC50值为 6.83 μM。BRD4-IN-4 选择性抑制 MV4-11 细胞系增殖并将细胞阻滞在 G1 期。BRD4-IN-4可用于研究 MLL 白血病。
T40305	BRD4-IN-2 BRD4-IN-2
	BRD4-IN-2 is a bromodomain BRD4 inhibitor with an IC 50 value of 9.9 nM.
T30580	BRD4-Kinases-IN-3 BRD4 kinases inhibitor 3,BRD4-Kinases inhibitor-3
	BRD4-Kinases-IN-3 is a dual BRD4-Kinases inhibitor that can be used as a value-added multi-targeted chemical probe for cancer therapy.
T10521	ODM-207 BET-IN-4,ODM207	Epigenetic Reader Domain	Chromatin/Epigenetic
	ODM-207 (BET-IN-4) 是一种 BET 溴区结构域蛋白的抑制剂，对 BRD4的 IC50值 ≤ 1 μM。
T61318	BRD4 Inhibitor-20	Epigenetic Reader Domain	Chromatin/Epigenetic
	BRD4 Inhibitor-20是一种有效的溴结构域蛋白4(BRD4)抑制剂，具有口服活性。BRD4 Inhibitor-20在癌细胞系中具有抗增殖活性，并被用于各种癌症的研究，如结肠癌。
T10522	BET-IN-6	Epigenetic Reader Domain	Chromatin/Epigenetic
	BET-IN-6 是一种有效且高亲和力的BRD2/BRD4抑制剂。BET-IN-6 是靶蛋白 BRD2/4 的配体，可用于合成 PROTAC BRD2/BRD4 degrader-1 。
T72636	BRD4 Inhibitor-26
	BRD4Inhibitor-26 是一种溴结构域蛋白 4(BRD4)抑制剂/一氧化氮供体。BRD4Inhibitor-26 抑制BRD4(BD1) 和BRD4(BD2)，IC50值分别为 0.82 μM 和 1.94 μM。BRD4Inhibitor-26 可用于卵巢癌的研究。
T78647	PROTAC BRD4 Degrader-16	PROTACs	PROTAC
	PROTACBRD4Degrader-16是一种高效的PROTAC BRD4降解剂，具有对BRD4(BD1)和BRD4(BD2)分别为34.58 nM及40.23 nM的IC50值。该化合物有效抑制G2/M阶段细胞周期蛋白B1（Cyclin B1）的表达，并显著诱导MV-4-11细胞的细胞凋亡（apoptosis）。
T63991	BRD4/CK2-IN-1
	BRD4/CK2-IN-1 是高效的、口服具有活力的 BRD4/CK2 (含溴结构域蛋白 4/酪蛋白激酶 2) 双靶点抑制剂，能够作用于 BRD4 (IC50: 180 nM) 和 CK2 (IC50: 230 nM)。在三阴性乳腺癌 (TNBC) 中，BRD4/CK2-IN-1 能够诱导细胞凋亡和自噬相关的细胞死亡。BRD4/CK2-IN-1 表现出显著的抗癌效果，且没有明显毒性。
T36628	PROTAC BRD4 Degrader-8 PROTAC BRD4 Degrader-8
	PROTAC BRD4 Degrader-8 is a potent BRD4 inhibitor, with IC50s of 1.1 nM and 1.4 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-8 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells[1]. PROTAC BRD4 Degrader-8 (compound 8; 6 days) inhibits the proliferation of PC3 prostate cancer cells, with an IC50 of 28 nM[1].PROTAC BRD4 Degrader-8 (4 h) suppresses MYC gene transcript in MV4-11 AML cells, with an IC50 of 11 nM[1].PROTAC BRD4 Degrader-8 (4 h) potently degra...
T74270	PROTAC BRD4 Degrader-17
	PROTACBRD4 Degrader-17 (compound 13i)，作为一种高效的 PROTACBRD4 降解剂，其 IC50 值分别为 29.54 nM（针对 BRD4(BD1)）和 3.82 nM（针对 BRD4(BD2)）。该化合物有效抑制 G2/M 相的细胞周期蛋白 B1 (Cyclin B1) 的表达，并在 MV-4-11 细胞中显著诱导细胞凋亡（apoptosis）。
T15399	GNE-207	Epigenetic Reader Domain	Chromatin/Epigenetic
	GNE-207 is a selective and orally bioavailable inhibitor of the bromodomain of CBP (IC50: 1 nM). It has a selective index of >2500-fold against BRD4 (1). GNE-207 displays excellent CBP potency (EC50: 18 nM for MYC expression in MV-4-11 cells).
T36103	TW9 TW9
	TW9 is a dual inhibitor of bromodomain 2 (BD2) in bromodomain-containing protein 4 (BRD4) and histone deacetylase 1 (HDAC1; IC50s = 0.074 and 0.29 μM, respectively).1It is selective for BD2 over BD1 in BRD4 (IC50= 0.72 μM) and for HDAC1 over HDAC2 (IC50= 2.5 μM). TW9 (50 nM) induces apoptosis in, and inhibits proliferation of, MIA PaCa-2 pancreatic cancer cells. It induces cell cycle arrest at the G1phase in HPAC pancreatic cancer cells when used at a concentration of 2 μM. TW9 acts synergistica...
T36800	EN219
	EN219 is a synthetic recruiter of the E3 ubiquitin ligase RNF114.1It binds to cysteine 8 (C8) in the intrinsically disordered region of RNF114 (RNF114-C8; IC50= 470 nM) and inhibits RNF114-induced autoubiquitination and p21 ubiquitination in a cell-free assay when used at a concentration of 50 μM. EN219 (1 μM) also interacts with cysteine residues in the tubulin β1 chain (TUBB1), heat shock protein 60 (Hsp60), also known as Hsp family D member 1 (HspD1), and histone H3.1 (HIST1H3A) in 231MFP hum...
T38381	CAY17c
	CAY17c is an inhibitor of bromodomain-containing protein 4 (BRD4; IC50= 0.71 μM), as well as class I histone deacetylases (HDACs; IC50s = 0.046, 0.058, 0.075, and 0.167 μM for HDAC1, -2, -3, and -8, respectively) and class IIb HDACs (IC50s = 0.073 and 0.923 μM for HDAC6 and HDAC10, respectively).1It is selective for these enzymes over BRD2, -3, and -T (IC50s = >20 μM for all), as well as over HDAC4, -5, -7, -9, and -11 (IC50s = >10 μM for all). CAY17c inhibits the proliferation of HCT116, SW620,...

化合物

Cat.No: T77339

Target: Epigenetic Reader Domain

Cat.No: T40305

Synonym: BRD4-IN-2

BRD4-Kinases-IN-3

Cat.No: T30580

Synonym: BRD4 kinases inhibitor 3,BRD4-Kinases inhibitor-3

Cat.No: T10521

Synonym: BET-IN-4,ODM207

Target: Epigenetic Reader Domain

BRD4 Inhibitor-20

Cat.No: T61318

Target: Epigenetic Reader Domain

Cat.No: T10522

Target: Epigenetic Reader Domain

BRD4 Inhibitor-26

Cat.No: T72636

PROTAC BRD4 Degrader-16

Cat.No: T78647

Target: PROTACs

BRD4/CK2-IN-1

Cat.No: T63991

PROTAC BRD4 Degrader-8

Cat.No: T36628

Synonym: PROTAC BRD4 Degrader-8

PROTAC BRD4 Degrader-17

Cat.No: T74270

Cat.No: T15399

Target: Epigenetic Reader Domain

Cat.No: T36103

Synonym: TW9

Cat.No: T36800

Cat.No: T38381

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼