Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T14694 |
BNC105
|
Microtubule Associated | Cytoskeletal Signaling |
BNC105 是一种微管蛋白聚合抑制剂,具有抗增殖和破坏肿瘤血管的特性。 | |||
T68273 |
BNC105P
|
||
BNC105P is a benzofuran-based vascular disrupting agent (VDA) prodrug with potential anti-vascular and antineoplastic activities. Upon administration vascular disrupting agent BNC105P, the disodium phosphate ester of BNC105, is rapidly converted to BNC105; in activated endothelial cells, BNC105 binds to tubulin and inhibits its polymerization, which may result in a blockage of mitotic spindle formation, cell cycle arrest, and disruption of the tumor vasculature. Hypoxic conditions ensue, deprivi... |