Cat. No. | Product Name | Target | Signaling Pathways |
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T10452 |
BACE1-IN-4
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BACE | Neuroscience |
BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2. | |||
T3161L |
BACE-IN-1 acetate
BACE-IN-1 acetate (350228-37-4,Free base) |
BACE | Neuroscience |
BACE-IN-1 acetate (BACE-IN-1 acetate (350228-37-4,Free base)) 已被用作 BACE1 抑制剂测定中的 β 位淀粉样前体蛋白 (APP) 裂解酶-1 (BACE1) 抑制剂。 β-位点淀粉样前体蛋白 (APP) 切割酶-1 (BACE1)是一种天冬氨酸蛋白酶,属于蛋白酶家族,由六个腔内半胱氨酸残基组成。这些残基有助于形成三个分子间二硫键和 N-连接的糖基化位点。 | |||
T79423 |
BuChE-IN-9
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BuChE-IN-9 (compound 22a) 作为eqBuChE的抑制剂,表现出相当的效力,具有173 nM的IC50值。除此之外,BuChE-IN-9对人BACE1、Aβ聚集及小鼠mGAT1和mGAT4也具有抑制作用,并且显示出显著的抗遗忘特性。 | |||
T35975 |
6,9-Dichloro-1,2,3,4-tetrahydroacridine
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6,9-Dichloro-1,2,3,4-tetrahydroacridine is a synthetic intermediate in the synthesis of tacrine-based acetylcholinesterase (AChE) inhibitors.1It is also an intermediate in the synthesis of multifunctional tacrine hybrids that possess radical scavenging, amyloid-β aggregation inhibitory, and/or β-secretase 1 (BACE1) inhibitory activities in addition to their activity as AChE inhibitors.2,3 1.Recanatini, M., Cavalli, A., Belluti, F., et al.SAR of 9-amino-1,2,3,4-tetrahydroacridine-based acetylchol... |