Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T26644 |
Apomine
SK&F-99085,APB-231-A2,APB-231-A-2,SR-9223i,SK&F-99085,SR-45023A |
HMG-CoA Reductase | Metabolism |
Apomine (SR-9223i) 是一种 HMG-CoA-还原酶抑制剂,可在体外促进骨髓瘤细胞的凋亡,并与体内骨髓瘤的调节有关。 Apomine 加速 3-羟基-3-甲基戊二酰-CoA 还原酶的降解并刺激低密度脂蛋白受体活性。 Apomine 通过下调 3-羟基-3-甲基戊二酰-CoA 还原酶来增强洛伐他汀对骨髓瘤细胞的抗肿瘤作用。 | |||
T28009 |
ME-3221
ME3221 |
||
Apomine is an inhibitor of HMG-CoA-reductase. It promotes apoptosis of myeloma cells in vitro and is associated with a modulation of myeloma in vivo. Apomine enhances the antitumor effects of lovastatin on myeloma cells by down-regulating 3-hydroxy-3-meth |