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Search Results for " antioxidant agent-8 "

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抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T72506	Antioxidant agent-8
	Antioxidant agent-8是一种口服活性的Aβ1-42沉积抑制剂。其抑制原纤维聚集的IC50值为11.15 µM，促进原纤维分解的IC50值为6.87 µM。此外，Antioxidant agent-8对Cu2+诱导的Aβ1-42原纤维聚集有抑制作用（IC50=3.69 µM），并能促进Cu2+诱导的Aβ1-42原纤维分解（IC50=3.35 µM）。该化合物具备抗氧化活性、抗炎活性、生物安全性、血脑屏障通透性和神经保护作用。
T36516	RC574 RC574
	RC574 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol .1It inhibits glutamate-induced cell death in HT22 cells (IC50= 276.2 nM) and mouse primary cortical neurons when used at a concentration of 3 μM. RC574 (3 μM) increases glutathione peroxidase 1 (GPX1) levels and GPX activity, as well as inhibits glutamate-induced mitochondrial superoxide anion production, in HT22 cells. It completely inhibits ferroptosis induced by the GPX4 inhibitor ...
T36515	RC363
	RC363 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol .1It reduces 2,2-diphenyl-1-picrylhydrazyl radicals by approximately 40% in a cell-free assay when used at a concentration of 25 μM. RC363 prevents glutamate-induced toxicity in HT22 cultured hippocampal cells (IC50= 234.5 nM) but does not reduce oxidant levels in these cells. It increases the levels of glutathione peroxidase 1 (GPX1) and the activity of GPX in glutamate-challenged HT2...

化合物

Antioxidant agent-8

Cat.No: T72506

Cat.No: T36516

Synonym: RC574

Cat.No: T36515

Cat. No.	Product Name	Target	Signaling Pathways
T6S1684	8-Gingerol	Antioxidant; Antibacterial; TRP/TRPV Channel	Membrane transporter/Ion channel; Microbiology/Virology; oxidation-reduction
	8-Gingerol 分离自姜的根状茎，是口服有效的 TRPV1激活剂，EC50值为5.0 µM。8-Gingerol 抑制 COX-2，还能抑制体外 H. pylori 的生长。

天然产物

Cat.No: T6S1684

Target: Antioxidant, Antibacterial, TRP/TRPV Channel

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