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Search Results for " antibacterial compound 1 "

94

抑制剂 & 化合物

16

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T10500	Antibacterial compound 1	Antibacterial	Microbiology/Virology
	Antibacterial compound 1 is an antibacterial compound.
T50034	1-{1H-pyrrolo[2,3-d]pyrimidin-4-yl}piperazine dihydrochloride	Others	Others
	1-{1H-pyrrolo[2,3-d]pyrimidin-4-yl}piperazine dihydrochloride （1-PPZ-DHC）是一种用作分子结构单元的化合物。它是天然产物哌嗪的类似物，具有广泛的生物活性，包括抗炎、抗肿瘤和抗菌活性，同时还被研究用于治疗神经系统疾病，如阿尔茨海默氏症和帕金森氏症。
T61104	Antibacterial agent 82
	Antibacterial agent 82 (compound 7p) 是一种抗菌剂。
T60634	Antibacterial agent 80
	Antibacterial agent 80 (compound 20) 具有抗菌活性。
T74999	Antibacterial agent 127
	Antibacterial agent 127 (Compound 23) 是一种有效的抗细菌 (antibacterial) 剂。
T61640	Antibacterial agent 77
	Antibacterial agent 77 (compound 12) 是一种抗菌剂。
T61149	Antibacterial agent 121
	Antibacterial agent 121 (Compound 10) demonstrates antibacterial properties and exhibits efficacy against mycobacterial strains while also possessing anti-inflammatory activity. This compound finds potential applications in Tuberculosis (TB) research [1].
T60865	Antibacterial agent 78
	Antibacterial agent 78 (compound 30) 是一种具有改善细胞毒性的抗菌剂。
T60582	Antibacterial agent 74
	Antibacterial agent 74 (compound 36) 具有抗沙门氏菌活性。
T61624	Antibacterial agent 106
	Antibacterial agent 106 (compound 8) is a highly effective orally active antibacterial compound with antibiofilm activity. It demonstrates potent antibacterial effects against multi-drug resistant (MDR)-Gram-positive pathogens, including the eradication of 99.7% of intracellular methicillin-resistant S. aureus (MRSA) harbored within macrophages [1].
T61123	Antibacterial agent 111
	Antibacterial agent 111 (Compound 3) exhibits potent antibacterial activity against B. cereus and K. pneumonia, with MIC values of 3.90 μg/mL and 0.49 μg/mL, respectively. It achieves this antibacterial effect by strongly binding to specific residues of tyrosyl-tRNA synthetase [1].
T61170	Antibacterial agent 96
	Antibacterial agent 96 (compound 4k) 是一种有效的抗菌剂。Antibacterial agent 96 对药物敏感和耐多药的结核分枝杆菌 (M.tuberculosis)显示出抗结核活性。Antibacterial agent 96 对 HepG2 和 Vero 细胞有毒性。
T61799	Antibacterial agent 75
	Antibacterial agent 75 (compound 24) possesses antibacterial properties. Its notable attribute is the ability to re-sensitize VRSA (Vancomycin-Resistant Staphylococcus aureus) strains to vancomycin, as reported in reference [1].
T61346	Ph-Ph+
	Ph-Ph+ is a hemiprotonic compound derived from the dimerization of phenanthroline (ph). It exhibits remarkable antitumor, antibacterial, and antifungal properties [1].
T62740	Antibacterial agent 110
	Antibacterial agent 110 (Compound 4e) 是一种有效的抗细菌 (antibacterial) 剂，作用于 P. aeruginosa (MIC: 1 μg/ml)。Antibacterial agent 110 可以使代谢停滞和细胞内氧化应激，并阻碍 DNA 复制。Antibacterial agent 110 可以破坏细胞膜，具有良好的抗菌膜作用。
T74272	Antifungal agent 84
	Antibacterial agent 84 是一种抗真菌化合物。Antibacterial agent 84 以 CNB1 依赖性方式抑制念珠菌。Antibacterial agent 84 抑制C. albicans 生物膜的活性。
T74502	Antibacterial agent 108
	Antibacterial agent 108 (Compound 1h) 是一种有效的抗细菌剂，对 MRSA 和一些抗生素抗性菌的 MIC 值均为 3 μM。
T61251	Antibacterial agent 97
	Antibacterial agent 97 (hit compound) 是一种有效的抗菌剂。Antibacterial agent 97 对大肠杆菌(E.coli)和金黄色酿脓葡萄球菌 (S.aureus)的 MIC 分别为 16 和 16 μg/mL[1]。
T60804	Antibacterial agent 114
	Antibacterial agent 114 (compound 1) 是一种有效的抗菌剂，其对铜绿假单胞菌、枯草芽孢杆菌、大肠杆菌、粪肠球菌、鼠伤寒沙门氏菌的 MIC 值分别为 625、625、625、625、625、1250 和 1250 μM。
T74715	Antibacterial agent 136
	Antibacterial agent 136 (compound 3) 是恶二唑酮类抗生素。Antibacterial agent 136 对 Staphylococcus aureus(MRSA) 具有很高的抗菌效力，MIC50值为 0.8 μM。
T61126	Antibacterial synergist 1
	Antibacterial synergist 1 (compound 20P) is a potent inhibitor of bacterial biofilm formation. It effectively suppresses the production of pyocyanin, with an IC 50 of 8.6 μM, and inhibits biofilm formation with an IC 50 of 4.5 μM. Antibacterial synergist 1 shows promise in the research of P. aeruginosa infections [1].
T73850	trans-β-Terpineol
	trans-β-terpineol 为单萜类化合物，在圆叶菊叶片中可分离提取。该化合物具备抗氧化及抗菌特性，在圆叶菊中主要承担抗菌生物活性作用。
T74977	Antibacterial agent 123
	Antibacterial agent 123 (compound 111) 是一种有效的膜破坏剂，可以对抗耐药的革兰氏阳性菌。
T60690	Antibacterial agent 122
	Antibacterial agent 122 (compound 15) 是一种硫脲衍生物，可用于研究结核病。Antibacterial agent 122 表现出低细胞毒性，并且具有抗分枝杆菌活性。
T75172	Antibacterial agent 143
	Antibacterial agent 143 (Compound 5a) 是一种抗菌 (antibacterial) 剂，对 B. subtilisATCC6633、. aureusATCC6538、P. aeruginosaATCC13525 和E. coliATCC35218 的 MIC 值分别为 25、25、50 和 50 μg/mL。
T83100	Antibacterial agent 161 trifluoromethanesulfonate
	Antibacterialagent 161 (trifluoromethanesulfonate) (Compound 6) 表现出抗菌特性，并对结肠癌和非小细胞肺癌细胞线显示出显著的抗增殖活性。
T60414	Antibacterial agent 73
	Antibacterial agent 73（化合物 7a）具有抗结核、抗菌和抗真菌活性。 Antibacterial agent 73 具有良好的抗结核活性，对 Mtb H37Rv 的 MIC 为 0.65 μg/mL。 Antibacterial agent 73在 MCF-7 乳腺癌细胞系中也表现出细胞毒性，IC 50 为 8.20 μM [1]。
T64197	Antibacterial agent 112
	Antibacterial agent 112 (compound 2) 是一种有效的抗菌剂 (antibacterial)。Antibacterial agent 112 对 P.aeruginosa (MIC: 625 μM)、S.mutans (MIC: 625 μM)、B.subtilis (MIC: 1250 μM)、E.coli (MIC: 1250 μM)、E.faecalis (MIC: 1250 μM)、S.typhimuriumand (MIC: 1250 μM) 和 S.aureus microorganisms (MIC: 1250 μM)具有抗菌活性。
T83097	Antibacterial agent 165
	Antibacterialagent 165 (compound 3) 是一种有效针对细菌 (bacterial) 的羟基喹啉衍生物抑制剂，具备抗耐甲氧西林金黄色葡萄球菌 (MRSA) 的能力。
T61284	Antibacterial agent 94
	Antibacterial agent 94 (compound 5b) is a highly effective antibacterial agent that demonstrates strong activity against various bacterial strains. Notably, Antibacterial Agent 94 is capable of eradicating MRSA persisters, highlighting its potential as a therapeutic solution. Its mechanism of action involves interference with the bacterial membrane and disruption of the phosphatidylglycerol (PG) synthesis pathway [1].
T61665	Antibacterial agent 118
	Antibacterial agent 118 (also known as compound 20) is a potent antimycobacterial compound with activity against various mycobacterial strains, including Mtb H37Ra, M. aurum, M. smegmatis, Mtb H37Rv, and M. avium. The minimum inhibitory concentration (MIC) values for Antibacterial agent 118 against these strains are 40.7 μM, 10.2 μM, 163.0 μM, 62.5 μM, and 62.5 μM, respectively. This compound holds potential for tuberculosis research [1].
T74622	Antibacterial agent 109
	Antibacterial agent 109 (Compound C-2) 是一种有效的抗细菌 (antibacterial) 剂，对革兰氏阳性和革兰氏阴性细菌均有效，且无诱变作用。Antibacterial agent 109 通过阻断新肽链的延伸抑制蛋白质合成。
T83098	Antibacterial agent 163
	Antibacterialagent 163 (compound 1) 是一种羟基喹啉衍生物，能有效抑制细菌 (bacterial)。该化合物特别针对耐甲氧西林金黄色葡萄球菌 (MRSA) 表现出抑制作用。
T75014	Antiproliferative agent-18
	Antiproliferative agent-18 (Compound 5k) 为具抗增殖、中度抗细菌 (anti-bacterial) 及抗真菌 (anti-fungi) 活性的化合物。
T61308	Antifungal agent 27
	Antifungal agent 27 (compound 7) is a chemical compound possessing antifungal properties. It exhibits moderate antibacterial activity and weak antifungal activity against MRSA and C. albicans SS5314, with minimal inhibitory concentration (MIC) values of 8 and 32 μg/mL, respectively [1].
T62792	14α-Demethylase/DNA Gyrase-IN-1
	14α-Demethylase/DNA Gyrase-IN-1 (Compound 7c) 是一种 14α-Demethylase/DNA Gyrase 的有效抑制剂，具有抗菌作用。
T74966	Antimicrobial agent-10
	Antimicrobial agent-10 是一种 SARS-CoV-2 抑制剂，具有良好的抗菌活性。
T82945	ATP Synthesis-IN-1
	ATP Synthesis-IN-1（Compound 4）为喹啉衍生物，有效抑制PA ATP合成，IC50为11.1μg/mL。本化合物亦展示抗菌特性，适用于研究耐药PA感染。
T74968	Antimicrobial agent-12
	Antimicrobial agent-12 是一种有效的抗菌剂，同时具有 SARS-CoV-2 抑制活性。
T64100	Antibacterial agent 81
	Antibacterial agent 81 是一种 DNA 转录抑制剂。Antibacterial agent 81 抑制金黄葡萄球菌 USA300 以及耻垢分枝杆菌 ATCC14468，MIC 值分别为 12.5 和 7.8 μM。Antibacterial agent 81 可用于感染的研究。
T82483	Elastase LasB-IN-1
	ElastaseLasB-IN-1 (Compound 4b) 是一种选择性弹性蛋白酶LasB抑制剂，展现出抗菌活性，其IC50值为76 nM。
T74269	Antibacterial agent 83
	Antibacterial agent 83 (compound 17h) 对各种耐万古霉素 Enterococcus faecalis(VRE) 和耐甲氧西林 Staphylococcus aureus(MRSA) 显示出有效的抗菌活性。Antibacterial agent 83 可以显着减少 MRSA 的生物膜形成，并表现出良好的选择性。Antibacterial agent 83 在人肝微粒体中代谢稳定。
T60666	Antibacterial agent 105
	Antibacterial agent 105 (Compound 17) 是一种喹诺酮类的 Phenanthrolinic 类似物。Antibacterial agent 105 对结核分枝杆菌表现出抗菌活性，MIC90值为2.64 μM。此外，Antibacterial agent 105 对不同种类的菌种都表现出抗菌活性，对M. smegmatis,M. aurum,M. marinum,BCG,E. aerogenes 和S. aureus 的 MIC90值分别为 11.18, 11.18，0.70，1.40，44.70 和 22.35 μM。
T79773	Antibacterial agent 158
	Antibacterialagent 158 (compound 6c) 是一种高效抗菌化合物，具有显著的抗微球菌以及对抗脓疱疮和艰难梭菌感染 (CDI) 的活性。
T60614	DHDPS-IN-1
	DHDPS-IN-1 (compound 8) 是二氢吡啶二羧酸合酶 (DHDPS)的抑制剂，IC50值为 39 μM，可用于抗菌和除草领域。
T78900	Antibacterial agent 157
	Antibacterialagent 157 (compound B12)，作为一种杀真菌剂，能够干扰Botrytis cinerea的蛋白质合成，主要应用于灰霉病防治的研究领域。
T16565	Ppc-1	Others	Others
	Ppc-1 is a chemical compound known for its inhibitory effects on the Gram-negative periodontopathogen Porphyromonas gingivalis. It acts as a mitochondrial uncoupler, enhancing mitochondrial oxygen consumption without affecting ATP production. Additionally, Ppc-1 serves as a cell-permeate inhibitor of interleukin-2 (IL-2). This compound exhibits various beneficial activities, including anti-obesity, antibacterial, and anti-inflammatory properties.
T72180	Acetyl-CoA Carboxylase-IN-1
	Acetyl-CoA Carboxylase-IN-1，一种有效的乙酰辅酶 A 羧化酶 (ACC) 抑制剂，具备抗菌活性，其 IC50 值小于 5 nM。
T61780	MtTMPK-IN-4
	MtTMPK-IN-4 (compound 2), a para-piperidine, is a highly potent inhibitor of thymidylate kinase (MtTMPK) in Mycobacterium tuberculosis, exhibiting an IC50 value of 6.1 μM. Additionally, it possesses remarkable inhibitory activity against tyrosinase. Furthermore, MtTMPK-IN-4 exhibits potent antibacterial properties [1] [2].
T61689	ThrRS-IN-1
	ThrRS-IN-1 (Compound 30d) 是一种threonyl-tRNA synthetase (ThrRS)抑制剂，对Salmonella entericaThrRS (SeThrRS) 的IC50值为 1.4 μM，Kd 值为 1.36 μM。 ThrRS-IN-1 同时靶向 ThrRS 的 tRNAThr 和 L-threonine 结合袋。ThrRS-IN-1 具有抗细菌 (antibacterial) 活性。

化合物

Antibacterial compound 1

Cat.No: T10500

Target: Antibacterial

1-{1H-pyrrolo[2,3-d]pyrimidin-4-yl}piperazine dihydrochloride

Cat.No: T50034

Target: Others

Antibacterial agent 82

Cat.No: T61104

Antibacterial agent 80

Cat.No: T60634

Antibacterial agent 127

Cat.No: T74999

Antibacterial agent 77

Cat.No: T61640

Antibacterial agent 121

Cat.No: T61149

Antibacterial agent 78

Cat.No: T60865

Antibacterial agent 74

Cat.No: T60582

Antibacterial agent 106

Cat.No: T61624

Antibacterial agent 111

Cat.No: T61123

Antibacterial agent 96

Cat.No: T61170

Antibacterial agent 75

Cat.No: T61799

Cat.No: T61346

Antibacterial agent 110

Cat.No: T62740

Antifungal agent 84

Cat.No: T74272

Antibacterial agent 108

Cat.No: T74502

Antibacterial agent 97

Cat.No: T61251

Antibacterial agent 114

Cat.No: T60804

Antibacterial agent 136

Cat.No: T74715

Antibacterial synergist 1

Cat.No: T61126

trans-β-Terpineol

Cat.No: T73850

Antibacterial agent 123

Cat.No: T74977

Antibacterial agent 122

Cat.No: T60690

Antibacterial agent 143

Cat.No: T75172

Antibacterial agent 161 trifluoromethanesulfonate

Cat.No: T83100

Antibacterial agent 73

Cat.No: T60414

Antibacterial agent 112

Cat.No: T64197

Antibacterial agent 165

Cat.No: T83097

Antibacterial agent 94

Cat.No: T61284

Antibacterial agent 118

Cat.No: T61665

Antibacterial agent 109

Cat.No: T74622

Antibacterial agent 163

Cat.No: T83098

Antiproliferative agent-18

Cat.No: T75014

Antifungal agent 27

Cat.No: T61308

14α-Demethylase/DNA Gyrase-IN-1

Cat.No: T62792

Antimicrobial agent-10

Cat.No: T74966

ATP Synthesis-IN-1

Cat.No: T82945

Antimicrobial agent-12

Cat.No: T74968

Antibacterial agent 81

Cat.No: T64100

Elastase LasB-IN-1

Cat.No: T82483

Antibacterial agent 83

Cat.No: T74269

Antibacterial agent 105

Cat.No: T60666

Antibacterial agent 158

Cat.No: T79773

Cat.No: T60614

Antibacterial agent 157

Cat.No: T78900

Cat.No: T16565

Target: Others

Acetyl-CoA Carboxylase-IN-1

Cat.No: T72180

Cat.No: T61780

Cat.No: T61689

Cat. No.	Product Name	Target	Signaling Pathways
T4S1452	Artemisic acid (+)-Artemisinic Acid,青蒿酸,Artemisinic acid	Antibacterial	Microbiology/Virology
	Artemisic acid ((+)-Artemisinic Acid) 是黄花蒿中分离得到的一种倍半萜，具有多种药理活性，如抗疟、抗菌和抗肿瘤活性，以及解热、化感和抗脂肪生成作用。
T5274	D-(+)-Phenyllactic acid D-3-苯乳酸,D-3-Phenyllactic acid	Endogenous Metabolite; Antibacterial	Metabolism; Microbiology/Virology
	D-(+)-Phenyllactic acid (D-3-Phenyllactic acid) 是一种由白地霉分泌得到的抗菌剂，可抑制部分来自人类和食品的革兰氏阳性菌以及来自人类的革兰氏阴性菌。
T75598	Aurachin SS
	Aurachin SS, 一种从Streptomycessp. NA04227分离的天然产物，为具抗菌活性的抗生素。
T75578	Apigravin
	Apigravin 是一种有效的抗菌剂。Apigravin 对 Bacillus subtilis 具有抗菌活性，MIC 值为 61 μM。
T75610	lsocryptomerin
	lsocryptomerin 是一种具有膜活性的抗真菌 (antifungal) 化合物，可从 Selaginella tamariscina 中分离得到。lsocryptomerin 能使真菌质膜去极化。lsocryptomerin 还具有抗癌和抗细菌 (antibacterial) 活性。
T74050	Allyl methyl trisulfide
	Allyl methyl trisulfide 是一种来自大蒜(Allium sativum L.)精油的挥发性有机化合物，具备抗菌、抗氧化和抗肿瘤活性。
T75577	3′-Omethyl-5′-hydroxydiplacone
	3′-Omethyl-5′-hydroxydiplacone（化合物 2）为C-6-香叶基黄酮类化合物，从毛泡桐果实乙醇提取物中分离出。此化合物对革兰氏阳性菌展现出抗菌活性。
T75507	1-Methyl-2-(8E)-8-tridecenyl-4(1H)-quinolinone
	1-Methyl-2-(8E)-8-tridecenyl-4(1H)-quinolinone 对幽门螺杆菌菌株 51 表现出有效的抗菌活性，MIC50 值和 MIC90 值分别为 22 µM 和 50 µM。该化合物展现了在研究胃及十二指肠溃疡方面的潜力。
T35532	Galegine hydrochloride
	Galegine hydrochloride, a guanidine derivative derived from G. officinalis, plays a role in inducing weight loss in mice and has contributed to the development of biguanides, including metformin and phenformin. This compound stimulates AMPK activation in 3T3-L1 adipocytes, L6 myotubes, H4IIE rat hepatoma, and HEK293 human kidney cell lines. Additionally, galegine hydrochloride exhibits antibacterial properties, particularly demonstrating a minimum inhibitory concentration of 4 mg/L against Staph...
T80019	17-Hydroxyneomatrine
	17-Hydroxyneomatrine 是一种从苦参 (Sophora flavescens) 提取的化合物，有效抑制人宫颈癌Hela细胞生长，并展现抗菌、抗过敏、抗肿瘤、抗心律失常、消肿、利尿、免疫调节等多种生物活性。
T83437	18-O-Demethylpederin
	18-O-Demethylpederin 是 pederin 的一种类似物，原先自隐翅虫科昆虫中分离得到。作为一种天然聚酮化合物，pederin 是非蛋白质昆虫毒素，展现了包含抗菌、抗病毒和抗肿瘤在内的广泛生物活性。
T75665	3-O-Methylellagic acid
	3-O-Methylellagic acid 是一种天然产物，从Myrciaria cauliflora 中分离得到，具有抗炎活性。3-O-Methylellagic acid 对葡萄糖转运有抑制作用。3-O-Methylellagic acid 具有抗菌活性，对葡萄球菌 ATCC 25923 菌株作用的 MIC 值为 32 μg/mL。
T75468	Asperglaucin B
	Asperglaucin B 是一种来自真菌Aspergillus chevalieriSQ-8 的烷基化水杨醛衍生物，具有抗菌活性。Asperglaucin B 对两种植物病原体Pseudomonas syringae pv actinidae(Psa)和Bacillus cereus 显示出有效的抗菌活性，MIC 值为 6.25 μM。
T72508	Palmatine hydroxide
	Palmatine hydroxide 是不可逆的口服活性IDO-1抑制剂，其对HEK 293-hIDO-1 和 rhIDO-1的IC50值分别为3 μM和157 μM。该化合物还能非竞争性抑制(WNV)NS2B-NS3蛋白酶，IC50值为96 μM。Palmatine hydroxide展现了抗癌、抗炎、神经保护、抗细菌和抗病毒的活性。
T75555	(6E,12E)-Tetradecadiene-8,10-diyne-1,3-diol
	'(6E,12E)-Tetradecadiene-8,10-diyne-1,3-diol' 是从白术根中分离出的一种具有抗菌活性的化合物，对 MRSA 显示出 4 - 32 μg/mL 的最小抑菌浓度（MIC），表现出对抗性细菌感染研究的潜力。
T35624	Ajoene
	Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs = 5-160 &#181g/ml) and Gram-negative bacteria (MICs = 136-200 &#181g/ml), as well as yeasts (MICs = 10-20 &#181g/ml).1Ajoene is cytotoxic to mouse melanoma cells (IC50= 18 &#181M), as well as human colon, lung, mammary, and pancreatic cancer cells (IC50s = 7-41 &#181M).2It reduces...

天然产物

Cat.No: T4S1452

Synonym: (+)-Artemisinic Acid,青蒿酸,Artemisinic acid

Target: Antibacterial

D-(+)-Phenyllactic acid

Cat.No: T5274

Synonym: D-3-苯乳酸,D-3-Phenyllactic acid

Target: Endogenous Metabolite, Antibacterial

Cat.No: T75598

Cat.No: T75578

Cat.No: T75610

Allyl methyl trisulfide

Cat.No: T74050

3′-Omethyl-5′-hydroxydiplacone

Cat.No: T75577

1-Methyl-2-(8E)-8-tridecenyl-4(1H)-quinolinone

Cat.No: T75507

Galegine hydrochloride

Cat.No: T35532

17-Hydroxyneomatrine

Cat.No: T80019

18-O-Demethylpederin

Cat.No: T83437

3-O-Methylellagic acid

Cat.No: T75665

Cat.No: T75468

Palmatine hydroxide

Cat.No: T72508

(6E,12E)-Tetradecadiene-8,10-diyne-1,3-diol

Cat.No: T75555

Cat.No: T35624

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上海市静安区江场三路238号8楼