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Cat. No. | Product Name | Target | Signaling Pathways |
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T25079 |
Aminopterin N-hydroxysuccinimide ester
Nhs-aminopterin,N-Hydroxysuccinimide aminopterin |
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Aminopterin N-hydroxysuccinimide ester is an antineoplastic agent with immunosuppressive properties. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase. Its binding affinity for dihydrof | |||
T7730L |
Aminopterin sodium
NSC739,NSC 739 [as the base],NSC-739 |
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Aminopterin sodium is an antineoplastic agent with immunosuppressive properties. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase. Its binding affinity for dihydrofolate reductase effe | |||
T24961 |
10-Deazaaminopterin
NSC 311469,NSC-311469,10-Deaza-aminopterin,NSC311469 |
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10-Deazaaminopterin is a poly-gamma-glutamyl metabolite of the experimental anticancer drug, a folic acid antagonist, antineoplastic agent enzyme inhibitor. | |||
T31465 |
Dihydroaminopterin
|
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Dihydroaminopterin is a derivative of aminopterin. | |||
T24963 |
10-Methyl-10-deazaaminopterin
|
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10-Methyl-10-deazaaminopterin is a folate analog that shows antitumor activity. | |||
T24976 | 3'-Fluoroaminopterin | ||
3'-Fluoroaminopterin is a folic acid antagonist agent. | |||
T29287 | 11-Thiohomoaminopterin | ||
11-Thiohomoaminopterin is a 11-thiohomofolic acid analog. | |||
T24972 |
2'-Fluoroaminopterin
|
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2'-Fluoroaminopterin is a folic acid antagonist agent. | |||
T31269 |
Deazaminopterin
CB-3702,CB3702,NCS-529860,CB 3702,NCS 529860 |
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Deazaminopterin is a bioactive chemical. | |||
T24966 |
11-Oxahomoaminopterin
NSC-325304,NSC 325304,NSC325304 |
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11-Oxahomoaminopterin exhibits antifolate activity against two folate-requiring microorganisms and inhibited Lactobacillus casei DHFR. | |||
T34823 |
Tetrahydroxyaminopterin
NSC524120,NSC 524120,NSC-524120 |
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Tetrahydroxyaminopterin is a bioactive chemical. | |||
T24978 |
5,10-Dideazaaminopterin
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5,10-Dideazaaminopterin is an antileukemic drug. | |||
T33742 |
NSC 184692
NSC-184692,NSC184692 |
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NSC 184692 is a aminopterin-derivative. | |||
T73085 |
Talotrexin
PT523 |
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Talotrexin (PT523) 是一种 Aminopterin 的类似物,是一种非聚谷氨酸化的经典抗叶酸剂 (antifolate)。 Talotrexin 是一种 RFC(还原型叶酸载体)的特异性抑制剂,可选择性地抑制 RFC 转运。Talotrexin 通过靶向 DHFR 抑制肿瘤生长显示出抗肿瘤活性。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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T7730 |
Aminopterin
APGA,氨基蝶呤,4-Aminofolic acid |
Antifolate | Cell Cycle/Checkpoint |
Aminopterin (4-Aminofolic acid) 是叶酸的 4-氨基衍生物,是叶酸拮抗剂,具有抗癌和免疫抑制活性,用于研究儿童白血病。它催化叶酸还原为四氢叶酸,竞争性抑制二氢叶酸还原酶,Ki 值为 3.7 pM。 |