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Search Results for " aminopeptidase n inhibitor "

5

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T36943	Aminopeptidase N Inhibitor
	Aminopeptidase N (AP-N) inhibitor is a reversible inhibitor of AP-N/CD13 (IC50 = 25 μM). It is selective for AP-N/CD13 over matrix metalloproteinase-9 (MMP-9), angiotensin converting enzyme (ACE), neutral endopeptidase (NEP), γ-glutamyl transpeptidase, and the serine proteases dipeptidyl peptidase 4 (DPP-4) and cathepsin G at a concentration of 1 mM. AP-N inhibitor is non-cytotoxic to U937 cells at a concentration of 100 μM.
T21696	SC-57461A N -甲基- N -[3 - [4 - (苯甲基)苯氧基]丙基Β-丙氨酸盐酸盐	Aminopeptidase	Metabolism
	SC-57461A 是一种口服有活力的非肽类白三烯 A4 (LTA4) 水解酶选择性抑制剂，它能够抑制重组人 (IC50: 2.5 nM) 、小鼠 (IC50: 3 nM) 和小鼠LTA4水解酶 (IC50: 23 nM) 。
T25940	Phebestin
	Phebestin is an aminopeptidase N inhibitor, produced by Streptomyces sp. MJ716-m3.
T24431	Matlystatin A
	Matlystatin A is an inhibitor of aminopeptidase. It shows multiple inhibitory activities against both aminopeptidase N and matrix metalloproteinases.
T61756	APN/AKT-IN-1
	APN/AKT-IN-1 is a potent dual inhibitor of aminopeptidase N (APN) and protein kinase B (AKT), exhibiting IC50 values of 0.21 μM and 0.27 μM for APN and AKT inhibition, respectively. This compound effectively suppresses the phosphorylation of glycogen synthase kinase 3 beta (GSK3β), which serves as an intracellular substrate of AKT [1].

化合物

Aminopeptidase N Inhibitor

Cat.No: T36943

Cat.No: T21696

Synonym: N -甲基- N -[3 - [4 - (苯甲基)苯氧基]丙基Β-丙氨酸盐酸盐

Target: Aminopeptidase

Cat.No: T25940

Cat.No: T24431

Cat.No: T61756

Cat. No.	Product Name	Target	Signaling Pathways
T3529	Bestatin hydrochloride 盐酸乌苯美司,Ubenimex hydrochloride,苯丁抑制素	Integrin; Aminopeptidase; Antibacterial; Antibiotic	Cytoskeletal Signaling; Metabolism; Microbiology/Virology
	Bestatin hydrochloride (Ubenimex hydrochloride) 是CD13(Aminopeptidase N)/APN 和leukotriene A4 hydrolase 抑制剂，可研究癌症。
T62258	Bestatin trifluoroacetate
	Bestatin trifluoroacetate (Ubenimex trifluoroacetate) 是一种 CD13 (Aminopeptidase N)/APN 和 leukotriene A4 hydrolase 抑制剂，经常用于研究癌症。
T14121	Actinonin (-)-Actinonin	Aminopeptidase	Metabolism
	Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces and a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM, it also is an apoptosis inducer. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase, it also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin has antiproliferative and antitumor activities[1][2][3][4][5].

天然产物

Bestatin hydrochloride

Cat.No: T3529

Synonym: 盐酸乌苯美司,Ubenimex hydrochloride,苯丁抑制素

Target: Integrin, Aminopeptidase, Antibacterial, Antibiotic

Bestatin trifluoroacetate

Cat.No: T62258

Cat.No: T14121

Synonym: (-)-Actinonin

Target: Aminopeptidase

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