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Cat. No. Product Name Target Signaling Pathways
T10426 AZ12601011

ALK Angiogenesis; Tyrosine Kinase/Adaptors
AZ12601011 is a highly potent and selective inhibitor of the TGFBR1 kinase, administered orally. It displays an IC50 of 18 nM and a Kd of 2.9 nM. By selectively targeting ALK4, TGFBR1, and ALK7, AZ12601011 effectively inhibits the phosphorylation of SMAD2. Additionally, it has been shown to hinder the growth and metastasis of mammary tumors [1].

化合物

AZ12601011
Cat.No: T10426
Synonym:
Target: ALK
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