Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T61612 |
ATX inhibitor 15
|
Others | Others |
ATX inhibitor 15 (compound 30) is an indole-based carbamate derivative with a strong inhibitory effect on autotaxin (ATX), demonstrated by an IC50 of 2.17 nM. Additionally, ATX inhibitor 15 effectively inhibits ATX activity in vivo and suppresses the expression of pro-fibrotic genes. Furthermore, ATX inhibitor 15 exhibits protective effects in lung fibrosis induced by Bleomycin in mice [1]. | |||
T4041 |
Ziritaxestat
GLPG1690 |
PDE | Metabolism |
Ziritaxestat (GLPG1690) 是一种创新的 autotaxin (ATX)抑制剂,其 IC50=131 nM,Ki=15 nM。 |