Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10410 |
ATX inhibitor 1
|
PDE | Metabolism |
ATX inhibitor 1是一种 ATX(IC50=1.23 nM, FS-3; 2.18 nM, bis-pNPP) 抑制剂。 | |||
T61612 |
ATX inhibitor 15
|
||
ATX inhibitor 15 (compound 30) is an indole-based carbamate derivative with a strong inhibitory effect on autotaxin (ATX), demonstrated by an IC50 of 2.17 nM. Additionally, ATX inhibitor 15 effectively inhibits ATX activity in vivo and suppresses the expression of pro-fibrotic genes. Furthermore, ATX inhibitor 15 exhibits protective effects in lung fibrosis induced by Bleomycin in mice [1]. | |||
T81804 | MEY-003 | ||
MEY-003是针对Autotaxin(ATX)的抑制剂,具有对hATX-β和hATX-ɣ的EC50值分别为460 nM和1.09 μM(LPC18:1分析条件下)。作为一种非竞争性抑制剂,其Ki值为432 nM。该化合物主要应用于ATX相关疾病的研究领域。 | |||
T72837 | Autotaxin-IN-6 | ||
Autotaxin-IN-6 (compound 23),一种ATX (自分泌运动分子)抑制剂,具有30 nM的IC50值,能够减少细胞迁移,适用于抗癌研究。 |