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Search Results for " asgpr "

10

抑制剂 & 化合物

8

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T82959	ASGPR ligand-1
	ASGPRligand-1为一脱唾液酸糖蛋白受体(ASGPR)配体，适用于多种疾病研究。
T82958	ASGPR modulator-1
	ASGPR modulator-1（Compound 5TJX）为一大环化合物，专用于蛋白质间相互作用研究。
T39370	tri-GalNAc-COOH	LYTACs	PROTAC
	Tri-GalNAc-COOH is a ligand for the asialoglycoprotein receptor (ASGPR) commonly employed in Lysosome Targeting Chimera (LYTAC) investigations.
T77945	TriGalNAc CBz	LYTACs	PROTAC
	TriGalNAc CBz 为 GalNAc 衍生物。作为一种 ASGPR 配体，TriGalNAc CBz 在 mRNA 药物递送及LYTAC研究中靶向溶酶体。
T83964	tri-GalNAc-PEG3-Azide
	tri-GalNAc-PEG3-Azide是一种用于溶酶体靶向嵌合体(LYTAC)研究与开发的功能化无乙酰神经氨酸糖蛋白受体(ASGPR)配体；每个分子包括三个ASGPR配体、一个PEG3连接器和一个准备用于接合的活性叠氮基团。绑定到ASGPR后，tri-GalNAc结合物通过ASGPR介导的内吞作用高效地被内化。tri-GalNAc接合可作为一种策略，以细胞特异性方式有效地将如RNA或Cas9复合体等货物递送至肝细胞。可用于生成LYTACs，或用染料标记以进行组织成像。
T81779	M-MoDE-A (2)	LYTACs	PROTAC
	M-MoDE-A (2)为双功能小分子，其作用机理包括促进通过ASGPR (去唾液酸糖蛋白受体) 介导的细胞外蛋白质降解。
T77948	Tri-GalNAc-DBCO	PROTACs	PROTAC
	Tri-GalNAc-DBCO是结合ASGPR以驱动蛋白质下调和靶向蛋白质降解的化合物，其中GalNAc作为肝细胞特异性ASGPR的高亲和力配体。
T77941	tri-GalNAc biotin	LYTACs	PROTAC
	tri-GalNAc biotin是一种针对降解物的小分子溶酶体靶向化合物，作为ASGPR（肝脏糖蛋白受体）的配体，它促进肝细胞通过ASGPR吸收中性抗生物素蛋白（NA），并将其运送至溶酶体内降解。该化合物适用于LYTAC（溶酶体靶向嵌合体）的研究。
T82537	D-MoDE-A (1)	LYTACs	PROTAC
	D-MoDE-A（1）是一种双功能小分子，它通过ASGPR（去唾液酸糖蛋白受体）介导外源蛋白的降解。
T80946	Tri-GalNAc-NHS ester	LYTACs	PROTAC
	Tri-GalNAc-NHS ester 是一种LYTAC，特别作为asialoglycoprotein receptor (ASGPR) 的配体，后者是肝细胞特有、参与细胞外包括膜蛋白在内的蛋白质降解的溶酶体靶向受体。该化合物在利用LYTAC进行蛋白质降解研究中扮演关键角色。

化合物

ASGPR ligand-1

Cat.No: T82959

ASGPR modulator-1

Cat.No: T82958

tri-GalNAc-COOH

Cat.No: T39370

Target: LYTACs

Cat.No: T77945

Target: LYTACs

tri-GalNAc-PEG3-Azide

Cat.No: T83964

Cat.No: T81779

Target: LYTACs

Tri-GalNAc-DBCO

Cat.No: T77948

Target: PROTACs

tri-GalNAc biotin

Cat.No: T77941

Target: LYTACs

Cat.No: T82537

Target: LYTACs

Tri-GalNAc-NHS ester

Cat.No: T80946

Target: LYTACs

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-05542	ASGR1 Protein, Human, Recombinant (His), Biotinylated asialoglycoprotein receptor 1,CLEC4H1,ASGPR1,HL-1,<...	Human	HEK293 Cells
	ASGR1 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.8 kDa and the accession number is P07306.
TMPY-02702	ASGR1 Protein, Human, Recombinant (His) ASGPR1,CLEC4H1,ASGPR,HL-1,asialoglycoprote...	Human	HEK293 Cells
	ASGR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.8 kDa and the accession number is P07306.
TMPY-06943	ASGR1 Protein, Human, Recombinant (His & Avi), Biotinylated CLEC4H1,HL-1,asialoglycoprotein receptor 1,ASGPR,	Human	HEK293 Cells
	ASGR1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 29.58 kDa and the accession number is P07306.
TMPH-03248	ASGR1 Protein, Rat, Recombinant (His & Myc) Asialoglycoprotein receptor 1,ASGP-R 1,rHL-1,Asgr1,HL-1,Asgr...	Rat	HEK293 Cells
	Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. ASGR1 Protein, Rat, Recombinant (His & Myc) is expressed in...
TMPH-02529	ASGR2 Protein, Mouse, Recombinant (His & Myc) ASGPR 2,HL-2,mHL-2,Asgr-2,Hepatic lectin 2,ASGP-R 2...	Mouse	E. coli
	Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. ASGR2 Protein, Mouse, Recombinant (His & Myc) is expressed ...
TMPY-02909	ASGR2 Protein, Human, Recombinant (His) HBXBP,ASGPR2,HL-2,asialoglycoprotein receptor 2,ASG...	Human	HEK293 Cells
	ASGR2 is a subunit of the asialoglycoprotein receptor. Asialoglycoprotein receptor, also known as the Ashwell receptor, which is specific for desialylated (galactosyl-terminal) glycoproteins and is expressed exclusively in hepatic parenchymal cells. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. ASGR2 is ...
TMPY-00671	ASGR1 Protein, Mouse, Recombinant (His) ASGPR1,Asgr,HL-1,asialoglycoprotein receptor 1,Asgr...	Mouse	HEK293 Cells
	ASGR1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28 kDa and the accession number is P34927.
TMPY-05349	ASGR1 Protein, Mouse, Recombinant (His), Biotinylated Asgr-1,asialoglycoprotein receptor 1,HL-1,ASGPR1,As...	Mouse	HEK293 Cells
	ASGR1 Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28 kDa and the accession number is P34927.

重组蛋白

ASGR1 Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-05542

Species: Human

Expression System: HEK293 Cells

ASGR1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02702

Species: Human

Expression System: HEK293 Cells

ASGR1 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-06943

Species: Human

Expression System: HEK293 Cells

ASGR1 Protein, Rat, Recombinant (His & Myc)

Cat.No: TMPH-03248

Species: Rat

Expression System: HEK293 Cells

ASGR2 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02529

Species: Mouse

Expression System: E. coli

ASGR2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02909

Species: Human

Expression System: HEK293 Cells

ASGR1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00671

Species: Mouse

Expression System: HEK293 Cells

ASGR1 Protein, Mouse, Recombinant (His), Biotinylated

Cat.No: TMPY-05349

Species: Mouse

Expression System: HEK293 Cells

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