Cat. No. | Product Name | Target | Signaling Pathways |
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T71552 |
ASC-JM-17
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ASC-JM-17 is an activator of both Nrf1 and Nrf2 proteins. ASC-JM17 acts on Nrf1, Nrf2 and Hsf1 to increase the expression of proteasome subunits, antioxidant enzymes and molecular chaperones. ASC-JM17 ameliorates toxicity of the mutant androgen receptor (AR) responsible for SBMA in cell, fly and mouse models. Knockdown of the Drosophila Nrf1 and Nrf2 ortholog cap ‘n’ collar isoform-C, but not Hsf1, blocks the protective effect of ASC-JM17 on mutant AR-induced eye degeneration in flies. | |||
T71550 | STAT3-IN-8 | STAT | JAK/STAT signaling; Stem Cells |
STAT3-IN-8(即化合物H172)是一种高效的STAT3抑制剂,具备在癌症研究中应用的潜力。 |