Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10358 |
Netarsudil Dihydrochloride
AR-13324 Dihydrochloride |
ROCK | Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells |
Netarsudil Dihydrochloride (AR-13324 Dihydrochloride) 是 Rho 相关蛋白激酶 (ROCK) 和去甲肾上腺素转运蛋白 (NET) 的抑制剂,可有效降低眼压 (IOP)。 | |||
T10358L |
AR-13324 M1 metabolite
|
Others | Others |
AR-13324 M1 metabolite is a hydrolysis metabolite of AR-13324 mesylate. | |||
T10357 |
AR-13324 analog mesylate
|
Others | Others |
AR-13324 analog mesylate is an inhibitor of Rho-kinase and a norepinephrine transporter and reduces intraocular pressure in normotensive monkey eyes. | |||
T10358L2 |
Netarsudil mesylate
AR-13324 (mesylate) |
Others | Others |
Netarsudil mesylate is an inhibitor of Rho-associated protein kinase (ROCK) and norepinephrine transporter (NET) with effective in intraocular pressure (IOP) reduction. | |||
T71118 | NEP-28 | ||
NEP-28 is an AR agonist. NEP28 is a new SARM exhibiting high selectivity for androgen receptor. NEP28 showed tissue-selective effect equivalent to or higher than existing SARMs. In addition, the administration of NEP28 increased the activity of neprilysin, a known Aβ-degrading enzyme. |