Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12575 |
Unesbulin
PTC596 |
Apoptosis; BMI-1 | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Unesbulin (PTC596) 是一种口服有效和选择性的 B 细胞特异性莫洛尼氏鼠白血病病毒整合位点 1 抑制剂。它在急性髓细胞白血病细胞中可下调 MCL-1 并诱导不依赖 p53 的线粒体凋亡,具有抗白血病作用。 | |||
T28455 |
ProTAME
pro-Tosyl-L-Arginine Methyl Ester |
||
ProTAME is an inhibitor of APC/CFzr and APC/CCdc20. Combinations of proTAME with topoisomerase inhibitors, doxorubicin and etoposide, significantly increase cell death in primary cells and Multiple Myeloma (MM) cell lines, particularly if TOPIIα levels ar |