Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T61051 |
ANO1-IN-1
|
Chloride channel | Membrane transporter/Ion channel |
ANO1-IN-1是一种选择性的 ANO1 通道阻断剂,对 ANO1 和 ANO2有抑制作用, IC50 值分别为 2.56 μM 和 15.43 μM。ANO1-IN-1 对胶质瘤细胞的增殖抑制作用显著。 | |||
T60846 | ANO1-IN-3 | ||
ANO1-IN-3 (Compound 3n) 可诱导细胞凋亡,是ANO1 的选择性抑制剂,IC50值为 1.23 μM。 | |||
T61608 |
ANO1-IN-2
|
||
ANO1-IN-2 (Compound 10q) is a potent and selective ANO1 channel blocker. It exhibits an IC50 value of 1.75 μM against ANO1 and 7.43 μM against ANO2. Furthermore, ANO1-IN-2 demonstrates significant anti-proliferative activity in glioblastoma cells [1]. | |||
T61818 | DFBTA | ||
DFBTA is a highly effective and orally active inhibitor of ANO1, specifically the calcium-activated chloride channel anoctamin-1. It exhibits potent inhibitory activity, with an IC 50 of 24 nM. Notably, DFBTA demonstrates significant analgesic efficacy in treating inflammatory pain [1]. |