Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T62848 |
AMG 837 hemicalcium
|
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AMG 837 hemicalcium 是一种有效的、口服具有活力的 GPR40/FFA1部分激动剂。AMG 837 hemicalcium 能够抑制 [3H]AMG 837 与人类 FFA1受体的特异性结合 (pIC50: 8.13)。AMG 837 hemicalcium 能够提高啮齿动物的胰岛素分泌,减少葡萄糖水平。 | |||
T14216 |
AMG 837
|
Others | Others |
AMG 837 was found to be a partial agonist on GPR40 with maximal activity 85% of that shown by DHA under our standard assay conditions. Overall, AMG 837 was both highly potent and selective in vitro. AMG 837 is a potent GPR40 agonist(EC50=13 nM) with a sup | |||
T14215 |
AMG 837 sodium salt
|
Others | Others |
AMG 837 sodium salt is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. IC50 value: 13 nM (EC50) [1] Target: GPR40 agonist AMG 837 displayed the expected t | |||
TQ0020 |
AMG 837 calcium hydrate
|
GPR | Endocrinology/Hormones; GPCR/G Protein |
AMG 837 calcium hydrate 是口服有效的 GPR40/FFA1部分激动剂,抑制 [3H]AMG 837 与人类 FFA1受体的特异性结合,pIC50为 8.13。AMG 837 calcium hydrate 可增强啮齿动物的胰岛素分泌并降低葡萄糖水平。 |