Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T62606 |
ALOX15-IN-2
|
Lipoxygenase | Metabolism |
ALOX15-IN-2 是一种有效的 ALOX15 亚油酸加氧酶 (linoleate oxygenase) 活性抑制剂,抑制ALOX15 直系同源物亚油酸 (LA) 和花生四烯酸 (AA)进行氧化作用 , IC50 分别为 1.55 和 2.79 μM。 | |||
T37265 |
15(R)-Lipoxin A4
15(R)-Lipoxin A4,AT-Lipoxin A4 |
||
Lipid-derived lipoxins are produced at the site of vascular and mucosal inflammation where they down-regulate polymorphonuclear leukocyte recruitment and function. 15(R)-Lipoxin A4 (15(R)-LXA4) is derived from the aspirin-triggered formation of 15(R)-HETE from arachidonic acid. [1] [2] 15(R)-LXA4 inhibits LTB4-induced chemotaxis, adherence, and transmigration of neutrophils with twice the potency of LXA4 demonstrating activity in the nM range.[2] [3] The anti-inflammatory effects of aspirin may... |