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Search Results for " akr1c2 "

Targets Recommended: NADPH

4

抑制剂 & 化合物

1

天然产物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T38684	AKR1C3-IN-4 AKR1C3-IN-4	NADPH	Metabolism
	AKR1C3-IN-4 是醛酮还原酶 1C3 (AKR1C3) 选择性抑制剂，IC50为 0.56 μM。它在去势抵抗性前列腺癌中有研究的价值。
T61790	AKR1C3-IN-6
	AKR1C3-IN-6 (Compound 1) is a powerful and specific inhibitor of AKR1C3, with IC50 values of 0.31 μM and 73.23 μM against AKR1C3 and AKR1C2, respectively. It demonstrates significant antitumor activity [1].
T61485	S07-2010
	S07-2010 is a potent pan-AKR1C inhibitor, effectively inhibiting AKR1C3, AKR1C4, AKR1C1, and AKR1C2 with IC50 values of 0.19, 0.36, 0.47, and 0.73 μM, respectively. This compound induces apoptosis in A549/DDP cells and enhances the cytotoxicity of chemotherapeutic agents in drug-resistant cells, making it a viable option for combating drug resistance. Furthermore, S07-2010 significantly inhibits the proliferation of drug-resistant cells [1].
T14151	AKR1C1-IN-1	NADPH	Metabolism
	AKR1C1-IN-1 是高选择性 AKR1C1抑制剂(Ki:4 nM)。

化合物

Cat.No: T38684

Synonym: AKR1C3-IN-4

Target: NADPH

Cat.No: T61790

Cat.No: T61485

Cat.No: T14151

Target: NADPH

Cat. No.	Product Name	Target	Signaling Pathways
T2899	Liquiritin Liquiritigenin-4'-O-glucoside,Liquiritoside,甘草苷	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Liquiritin (Liquiritigenin-4'-O-glucoside) 是一种从甘草中分离出的类黄酮，是一种竞争性的 AKR1C1 抑制剂，对 AKR1C1，AKR1C2 和 AKR1C3 的 IC50分别为 0.62 μM，0.61 μM 和 3.72 μM，在体内有效抑制 AKR1C1 介导的孕酮代谢。它是一种抗氧化剂，具有神经保护、抗癌、抗炎的活性。

天然产物

Cat.No: T2899

Synonym: Liquiritigenin-4'-O-glucoside,Liquiritoside,甘草苷

Target: Reactive Oxygen Species

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03497	AKR1C2 Protein, Human, Recombinant (His) AKR1C2,HBAB,SRXY8,AKR1C-pseudo,al...	Human	E. coli
	AKR1C2 is a member of the aldo/keto reductase superfamily, which consists of more than 4 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. AKR1C2 gene shares high sequence identity with three other gene ...
TMPJ-00207	AKR1C2 Protein, Human, Recombinant 3-Alpha-HSD3,Chlordecone Reductase Homolog HAKRD,2-...	Human	E. coli
	Aldo-Keto Reductase Family 1 Member C2 (AKR1C2) plays a role in concert with the 5-α/5-β-Steroid Reductases to convert Steroid hormones into the 3-α/5-α and 3-α/5-β-Tetrahydrosteroids. AKR1C2 catalyzes the inactivation of the most potent androgen 5-α-Dihydrotestosterone (5-α-DHT) to 5-α-Androstane-3-α, 17-β-diol (3-α-diol).

重组蛋白

AKR1C2 Protein, Human, Recombinant (His)

Cat.No: TMPY-03497

Species: Human

Expression System: E. coli

AKR1C2 Protein, Human, Recombinant

Cat.No: TMPJ-00207

Species: Human

Expression System: E. coli

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