Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T14151 |
AKR1C1-IN-1
|
NADPH | Metabolism |
AKR1C1-IN-1 是高选择性 AKR1C1抑制剂(Ki:4 nM)。 | |||
T19999 |
1-Tetralol, (S)-
(S)-(+)-1,2,3,4-四氢-1-萘酚,(S)-Tetralin-1-ol,(S)-(+)-1,2,3,4-Tetrahydro-1-naphthol,(S)-1-Hydroxytetralin,J330.337C |
Others | Others |
1-Tetralol, (S)- ((S)-1-Hydroxytetralin) 可在细胞实验中用作 AKR1C1 的底物。 | |||
T61485 | S07-2010 | ||
S07-2010 is a potent pan-AKR1C inhibitor, effectively inhibiting AKR1C3, AKR1C4, AKR1C1, and AKR1C2 with IC50 values of 0.19, 0.36, 0.47, and 0.73 μM, respectively. This compound induces apoptosis in A549/DDP cells and enhances the cytotoxicity of chemotherapeutic agents in drug-resistant cells, making it a viable option for combating drug resistance. Furthermore, S07-2010 significantly inhibits the proliferation of drug-resistant cells [1]. |